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mechanism 1,055 words KG: GABA
Contents

GABA Signaling Pathway

⚙ Mechanism Info
NameGABA
Key Genes/ProteinsABCA7, ACTB, Actin, ADRA2B, Akt, AKT
Related Diseasesacetylcholine, Aging, AGING, Als, ALS
Linked Hypotheses11 hypotheses

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Knowledge Graph

Agent Input

Related Hypotheses (84)

Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.71Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70Microglial Purinergic Reprogramming
Score: 0.70Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.70Mechanosensitive Ion Channel Reprogramming
Score: 0.70Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69Ocular Immune Privilege Extension
Score: 0.69Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.69Ganglioside Rebalancing Therapy
Score: 0.69Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69Hypocretin-Neurogenesis Coupling Therapy
Score: 0.69TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution
Score: 0.68Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A
Score: 0.67Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
← Prevpg 2/5Next →

Related Analyses (30)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completedSleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedSynaptic pruning by microglia in early AD
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (3)

Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.40Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40Non-Dopaminergic Neurotransmitter Degeneration in PD - Exper
clinical · proposed · Score: 0.40

See Also (7)

acetylcholine
general · KG edge: co_discussedACTB Gene
gene · KG edge: activatesadra2b Gene
gene · KG edge: expressed_inAKT1 Gene
gene · KG edge: interacts_withGene Page: ALS4 (SENATAXIN)
gene · KG edge: activates

Knowledge Graph (12 edges)

GABA associated_with MTOR
GABA associated_with TFEB
AKT associated_with GABA
BACE1 associated_with GABA
TAU associated_with GABA
GABA associated_with neuroinflammation
GABA associated_with serotonin
GABA associated_with GABAergic neurons
GABA interacts_with GABARAP
FLCN interacts_with GABA

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