gene 707 words KG: FLCN
Contents

FLCN Gene

🧬 Gene Info
Gene SymbolFLCN
Full NameFolliculin
Chromosome17p11.2
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionneurons and glia - Highest expression in: - Cerebral cortex - [Hippocampus](/brain-regions/hippocamp
PathwaysmTOR, mtor, AMPK, mTOR Signaling
UniProt IDQ8IVG7
GeneCardsFLCN
Human Protein AtlasFLCN
Associated DiseasesALS, Kidney Cancer
Known Drugs/Compoundsrapamycin
InteractionsActin, ALS, AMPK, AMYOTROPHIC LATERAL SCLEROSIS, AND, AUTOPHAGY
KG Connections127 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (11)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Transcriptional Autophagy-Lysosome Coupling
Score: 0.88
APOE-Dependent Autophagy Restoration
Score: 0.85
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.81
Autophagosome Maturation Checkpoint Control
Score: 0.71

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

Amyotrophic Lateral Sclerosis
redirect · KG edge: interacts_with
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: activates
fip200
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

mitochondrial respiratory chain deficiency contributes_to FLCN
FNIP1 interacts_with FLCN
FLCN activates TFEB
MTOR regulates FLCN
ULK1 regulates FLCN
TFE3 regulates FLCN
FLCN regulates TFEB
MTOR interacts_with FLCN
TBK1 activates FLCN
MITF activates FLCN

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