| Gene Symbol | VPS13D |
| Chromosome | 1p36.22 |
| Protein Type | Gene |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 500 kDa |
| Amino Acids | 377 aa |
| Exons | 76 |
| GeneCards | VPS13D |
| Human Protein Atlas | VPS13D |
| N-terminal Domain | Mediates protein-protein interactions and membrane association |
| Chorein Domain | The central domain responsible for lipid transfer activity between membranes |
| C-terminal Regions | Involved in organelle targeting and regulation |
| Spinocerebellar Ataxia (SCA) | Characterized by progressive cerebellar ataxia, dysarthria, and oculomotor abnormalities |
| Hereditary Spastic Paraplegia (HSP) | Characterized by progressive lower limb spasticity and weakness |
| Alzheimer's Disease | Altered VPS13D expression reported in AD brains; may affect APP processing and Aβ metabolism through membrane trafficking pathways |
| Associated Diseases | Ms, Parkinson |
| Interactions | PARKIN, STING, UBIQUITIN |
| KG Connections | 18 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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