gene 1,007 words KG: VDAC1
Contents

VDAC1 — Voltage Dependent Anion Channel 1

🧬 Gene Info
Gene SymbolVDAC1
Full NameVoltage Dependent Anion Channel 1
Chromosome5q31
Protein TypeChannel
FunctionVDAC1 encodes the voltage-dependent anion channel 1, also known as porin.
Primary ExpressionBrain, Heart, Liver, Kidney
Molecular Weight31 kDa
PathwaysApoptosis, Autophagy, Er Stress, Glycolysis, Mitochondrial Function
UniProt IDP21796
NCBI Gene ID7416
Ensembl IDENSG00000110833
GeneCardsVDAC1
Human Protein AtlasVDAC1
Associated DiseasesALS, Alzheimer, Alzheimer's disease, amyotrophic lateral sclerosis
Interactionsaco2, ACO2, AKT, ALS, ALZHEIMER'S DISEASE, AMPK
SciDEX HypothesesMitochondrial Contact Site Stabilization
KG Connections499 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (26)

Quantum Coherence Disruption in Cellular Communication
Score: 0.63
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor
Score: 0.53
← Prevpg 2/2

Related Analyses (11)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (4)

Live-cell microscopy of mitochondria-lysosome contacts and c
exploratory · proposed · Score: 0.90
MLCS Quantification in Parkinson's Disease
validation · proposed · Score: 0.40
s:** - Test MCU overexpression specifically in layer II neur
falsification · proposed · Score: 0.40
Exercise-BDNF-Mitophagy Biomarker Study in PD
clinical · proposed · Score: 0.40

See Also (10)

Astrocytes
cell · KG edge: activates
ATP P2X3 Receptor Neurons
cell · KG edge: activates
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
ACO2 — Aconitase 2
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

VDAC1 activates DRP1
VDAC1 activates DNM1L
VDAC1 activates OPA1
DNM1L activates VDAC1
DRP1 activates VDAC1
VDAC1 activates AKT
CXCL10 activates VDAC1
STING activates VDAC1
CGAS activates VDAC1
IRF3 activates VDAC1

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