Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ALZHEIMERS_DISEASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | ALZHEIMERS_DISEASE |
| Key Genes/Proteins | BAG3, C3, MICROGLIA, MIRNAS, SNCA |
| Related Diseases | MULTIPLE_SCLEROSIS, PARKINSONS_DISEASE, REACTIVE_GLIOSIS |
| Related Pathways | GLYCOLYSIS, MITOPHAGY, MTOR_SIGNALING, PROTEOME, SYNAPSE_PATHWAY |
Knowledge base pages for this entity
graph TD
ALZHEIMERS_DISEASE["ALZHEIMERS_DISEASE"]
ALZHEIMERS_DISEASE ---|"associated"| PARKINSONS_DISEASE["PARKINSONS_DISEASE"]
ALZHEIMERS_DISEASE ---|"associated"| MULTIPLE_SCLEROSIS["MULTIPLE_SCLEROSIS"]
C3["C3"] -->|"contributes to"| ALZHEIMERS_DISEASE
MEMANTINE["MEMANTINE"] -->|"treats"| ALZHEIMERS_DISEASE
TAU["TAU"] ---|"associated"| ALZHEIMERS_DISEASE
p_tau181["p_tau181"] ---|"associated"| ALZHEIMERS_DISEASE
amyloid_beta["amyloid_beta"] ---|"associated"| ALZHEIMERS_DISEASE
ASTROCYTES["ASTROCYTES"] ---|"associated"| ALZHEIMERS_DISEASE
SYNAPSE_PATHWAY["SYNAPSE_PATHWAY"] ---|"associated"| ALZHEIMERS_DISEASE| Target | Relation | Type | Str |
|---|---|---|---|
| PARKINSONS_DISEASE | associated_with | disease | 0.56 |
| MULTIPLE_SCLEROSIS | associated_with | disease | 0.56 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MICROGLIA | associated_with | gene | 0.90 |
| MIRNAS | associated_with | gene | 0.90 |
| TAU | associated_with | protein | 0.87 |
| entorhinal_cortex_layer_II | early_vulnerability | brain_region | 0.80 |
| amyloid_beta | associated_with | protein | 0.72 |
| p_tau181 | associated_with | protein | 0.72 |
| circadian_disruption | associated_with | phenotype | 0.70 |
| MTOR_SIGNALING | associated_with | pathway | 0.64 |
| ASTROCYTES | associated_with | cell_type | 0.64 |
| C3 | contributes_to | protein | 0.64 |
| SYNAPSE_PATHWAY | associated_with | pathway | 0.64 |
| NEFL | associated_with | protein | 0.64 |
| MEMANTINE | treats | drug | 0.64 |
| REACTIVE_GLIOSIS | associated_with | phenotype | 0.64 |
| tau | associated_with | protein | 0.60 |
| TGM2 | associated_with | gene | 0.60 |
| TREM2 | associated_with | gene | 0.60 |
| PROTEOME | associated_with | pathway | 0.56 |
| BAG3 | associated_with | protein | 0.56 |
| SNCA | associated_with | gene | 0.56 |
| GLYCOLYSIS | associated_with | pathway | 0.56 |
| MITOPHAGY | associated_with | pathway | 0.56 |
| PDGFRB | associated_with | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
spatial memory | 2026-04-08 | 7 hypotheses Top: 0.455
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.696
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.639
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 6 · Score: 0.95 · 2026-04-10
closed · Rounds: 4 · Score: 0.95 · 2026-04-09
closed · Rounds: 4 · Score: 0.95 · 2026-04-01
Hypotheses and analyses mentioning ALZHEIMERS_DISEASE in their description or question text
No additional research found