| Gene Symbol | TET1 |
| Full Name | Tet Methylcytosine Dioxygenase 1 |
| Chromosome | 10q21.3 |
| Protein Type | Gene |
| Function | Unlike passive demethylation (which occurs during DNA replication without maintenance of methylation marks), TET1-mediated demethylation is an active, enzyme-driven process |
| Primary Expression | embryonic stem cells and neural progenitor cells, and is essential for pluripotency and neurogenesis |
| Amino Acids | 2136 aa |
| Pathways | epigenetic regulation, neurotrophin signaling, unfolded protein response |
| UniProt ID | Q8NFU7 |
| NCBI Gene ID | 80312 |
| Ensembl ID | ENSG00000138336 |
| OMIM | 607042 |
| GeneCards | TET1 |
| Human Protein Atlas | TET1 |
| CXXC Domain | A cysteine-rich DNA-binding domain that specifically recognizes unmethylated CpG islands, targeting TET1 to promoter regions |
| Associated Diseases | Rett Syndrome, Alzheimer Disease, Parkinson Disease, Intellectual Disability |
| Known Drugs/Compounds | Arsenic |
| Interactions | BDNF, DNA, DNMT1, ERK, GENES, IFN |
| KG Connections | 34 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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