gene 1,532 words KG: TET3
Contents

TET3 Gene

🧬 Gene Info
Gene SymbolTET3
Full NameTet Methylcytosine Dioxygenase 3
Chromosome2p13.1
Protein FamilyTET family (Fe(II) and 2-oxoglutarate-dependent dioxygenases)
Functioncatalyzing DNA demethylation
Primary Expressionneurons throughout the brain: - Cerebral cortex: Pyramidal neurons in layers 2-6 - Hippocampus: CA1, CA3, and dentate gyrus granule cells -
Amino Acids298 aa
UniProt IDQ8IU60
NCBI Gene ID200316
Ensembl IDENSG00000196950
OMIM617555
GeneCardsTET3
Human Protein AtlasTET3
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsBMAL1, DNA, OCT4, STING, TET1, TET2
KG Connections18 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Agent Input

Related Hypotheses (10)

Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.98
Circadian Clock-Autophagy Synchronization
Score: 0.76
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66
Temporal Decoupling via Circadian Clock Reset
Score: 0.54

Related Analyses (6)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

See Also (6)

Neurodegeneration
disease · KG edge: implicated_in
Epigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: inhibits
Genes
index · KG edge: regulates
BMAL1 (ARNTL) Gene
gene · KG edge: inhibits
CLOCK Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

CLOCK regulates TET3
BMAL1 inhibits TET3
OCT4 activates TET3
TET1 activates TET3
TET2 activates TET3
TET1 associated_with TET3
TET2 associated_with TET3
DNMT3A regulates TET3
MECP2 regulates TET3
STING activates TET3

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