gene 697 words KG: GAK
Contents

GAK Gene

🧬 Gene Info
Gene SymbolGAK
Chromosome6p21.1.
Protein TypeSerine/Threonine Kinase
Functionis a serine/threonine kinase encoded by the GAK gene on chromosome 6p21.
Molecular Weight165 kDa
Amino Acids505 aa
Exons43
PathwaysmTOR
GeneCardsGAK
Human Protein AtlasGAK
N-terminal kinase domainSerine/threonine kinase activity
Central clathrin-binding domainMediates interaction with clathrin-coated pits
C-terminal Hsc70-binding domainRegulates chaperone-mediated protein folding
Associated DiseasesAls, Ms, Parkinson
KG Connections28 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (16)

APOE-Dependent Autophagy Restoration
Score: 0.88
Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Extracellular Vesicle Biogenesis Modulation
Score: 0.58

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

Parkinson Basal Ganglia Circuit
circuit · KG edge: associated_with
Neurodegeneration
disease · KG edge: implicated_in
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: associated_with
DNAJC6 — DnaJ Heat Shock Protein Family Member A6
gene · KG edge: associated_with
FOXO1 Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

PARKIN associated_with GAK
LRRK2 associated_with GAK
GAK associated_with SYNJ1
GAK associated_with DNAJC6
GAK associated_with PARK2
FOXO1 expressed_in GAK
DGKQ associated_with GAK
GAK associated_with GBA
GAK associated_with SNCA
PARKINSON'S DISEASE associated_with GAK

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