gene 2,825 words KG: ADCY3
Contents

ADCY3 — Adenylate Cyclase 3

🧬 Gene Info
Gene SymbolADCY3
Full NameAdenylate Cyclase 3
Chromosome2p23.3
Protein TypeEnzyme
Functionis a member of the adenylate cyclase family of enzymes that catalyze the conversion of ATP to cyclic AMP (cAMP), a ubiquitous second messenger critical for cellular signaling.
Primary Expressionolfactory sensory neurons where it plays a critical role in odor detection and signal transduction
Molecular Weight140 kDa
Amino Acids244 aa
UniProt ID[O60236](https://www.uniprot.org/uniprot/O60236)
Ensembl IDENSG00000138031
OMIM600019
GeneCardsADCY3
Human Protein AtlasADCY3
Associated Diseasesobesity, Alzheimer's Disease
InteractionsGDNF, GFRAL, HDAC6, HEDGEHOG, SHH
KG Connections16 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (7)

Adenosine-Astrocyte Metabolic Reset
Score: 0.73
Circadian Clock-Autophagy Synchronization
Score: 0.76
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
Smartphone-Detected Motor Variability Correction
Score: 0.74
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Microbial Inflammasome Priming Prevention
Score: 0.65
Temporal Decoupling via Circadian Clock Reset
Score: 0.54

Related Analyses (5)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived

See Also (7)

Neurodegeneration
disease · KG edge: implicated_in
GDNF (Redirect)
redirect · KG edge: activates
HDAC6 (Redirect)
redirect · KG edge: activates
GFRAL Gene - GDNF Receptor Alpha Like
gene · KG edge: activates
SHH — Sonic Hedgehog
gene · KG edge: activates

Knowledge Graph (12 edges)

HDAC6 activates ADCY3
GDNF activates ADCY3
SHH activates ADCY3
GFRAL activates ADCY3
ADCY3 activates HDAC6
ADCY3 activates SHH
ADCY3 activates GFRAL
ADCY3 activates GDNF
ADCY3 cleaves LAMP2A
ADCY3 activates Als

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