| Gene Symbol | NOTCH1 |
| Chromosome | 9q34.3 |
| Protein Type | Receptor |
| Function | The first cleavage is mediated by ADAM10/TACE (alpha-secretase), and the second by gamma-secretase, releasing the Notch intracellular domain (NICD). |
| Primary Expression | Cerebral cortex, Hippocampus, Neural stem cells, Vascular endothelium |
| Molecular Weight | 272 kDa |
| Pathways | NOTCH, Notch, Notch signaling, Notch Signaling |
| UniProt ID | P46531 |
| NCBI Gene ID | 4851 |
| Ensembl ID | ENSG00000148400 |
| OMIM | 190198 |
| GeneCards | NOTCH1 |
| Human Protein Atlas | NOTCH1 |
| Neurogenesis | Maintains neural stem cell pools and regulates differentiation into neurons or glia |
| Synaptic plasticity | Modulates long-term potentiation (LTP) and memory formation |
| Associated Diseases | Als, Alzheimer, Alzheimer's Disease, Autoimmune, Cancer |
| Interactions | AKT, AKT1, ALDH1L1, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK |
| KG Connections | 496 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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