gene 893 words KG: LMNA
Contents

LMNA Gene

🧬 Gene Info
Gene SymbolLMNA
Chromosome1q22
Protein TypeProtein
Function### Nuclear Lamina Structure
Primary ExpressionUniversal (all cell types)
Molecular Weight72 kDa
Amino Acids33 aa
Exons12
Pathwayscalcium_homeostasis
UniProt IDP02545
NCBI Gene ID3999
Ensembl IDENSG00000160789
OMIM150330
GeneCardsLMNA
Human Protein AtlasLMNA
Associated DiseasesAD, Aging, ALI, Als, Alzheimer
InteractionsA2M, ABCD3, ACETYL-COA, Actin, AGING, ALS
KG Connections817 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (31)

Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68
Complement C1q Subtype Switching
Score: 0.66
RNA Granule Nucleation Site Modulation
Score: 0.66
Nucleolar Stress Response Normalization
Score: 0.65
Glial Glycocalyx Remodeling Therapy
Score: 0.65
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.62
VCP-Mediated Autophagy Enhancement
Score: 0.59
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
← Prevpg 2/2

Related Analyses (9)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

See Also (9)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
A2M Gene
gene · KG edge: interacts_with
ABCD3 Gene
gene · KG edge: interacts_with
AMBRA1 Gene
gene · KG edge: interacts_with
Alzheimer Indonesia
institution · KG edge: interacts_with

Knowledge Graph (12 edges)

LMNA causes DCM
LMNA encodes Lamin_AC
LMNA regulates calcium_homeostasis
NCSTN interacts_with LMNA
FAS interacts_with LMNA
TNF interacts_with LMNA
LMNA interacts_with APH1B
LMNA interacts_with APOE
LMNA interacts_with IL6
LMNA interacts_with SREBF1

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