gene 893 words KG: LMNA
Contents

LMNA Gene

🧬 Gene Info
Gene SymbolLMNA
Chromosome1q22
Protein TypeProtein
Function### Nuclear Lamina Structure
Primary ExpressionUniversal (all cell types)
Molecular Weight72 kDa
Amino Acids33 aa
Exons12
Pathwayscalcium_homeostasis
UniProt IDP02545
NCBI Gene ID3999
Ensembl IDENSG00000160789
OMIM150330
GeneCardsLMNA
Human Protein AtlasLMNA
Associated DiseasesAD, Aging, ALI, Als, Alzheimer
InteractionsA2M, ABCD3, ACETYL-COA, Actin, AGING, ALS
KG Connections817 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (31)

APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
CYP46A1 Overexpression Gene Therapy
Score: 0.98
APOE-Dependent Autophagy Restoration
Score: 0.88
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Circadian Clock-Autophagy Synchronization
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
PARP1 Inhibition Therapy
Score: 0.74
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
Phase-Separated Organelle Targeting
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Stress Granule Phase Separation Modulators
Score: 0.72
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Complement C1q Mimetic Decoy Therapy
Score: 0.69
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
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Related Analyses (9)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

See Also (9)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
A2M Gene
gene · KG edge: interacts_with
ABCD3 Gene
gene · KG edge: interacts_with
AMBRA1 Gene
gene · KG edge: interacts_with
Alzheimer Indonesia
institution · KG edge: interacts_with

Knowledge Graph (12 edges)

LMNA causes DCM
LMNA encodes Lamin_AC
LMNA regulates calcium_homeostasis
NCSTN interacts_with LMNA
FAS interacts_with LMNA
TNF interacts_with LMNA
LMNA interacts_with APH1B
LMNA interacts_with APOE
LMNA interacts_with IL6
LMNA interacts_with SREBF1

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