gene 2,503 words KG: FOXA2
Contents

FOXA2 — Forkhead Box A2

🧬 Gene Info
Gene SymbolFOXA2
Full NameForkhead Box A2
Chromosome20p11.22.
Protein TypeTranscription Factor
Functionis a forkhead family transcription factor that plays critical roles in the development and maintenance of dopaminergic neurons in the midbrain.
Molecular Weight48.3 kDa
Amino Acids110 aa
PathwaysAngiogenesis
Ensembl IDENSG00000156413
GeneCardsFOXA2
Human Protein AtlasFOXA2
Associated DiseasesALS, Alzheimer, Alzheimer'S Disease, dementia, disease, neurodegeneration
InteractionsDAT, EN1, EN2, FOXO1, FOXO3, INSULIN RESISTANCE
KG Connections79 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (23)

Correcting Gut Microbial Dopamine Imbalance to Support Syste
Score: 0.61
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73

Related Analyses (7)

Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (8)

Ferroptosis Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Regulated Necrosis Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Synaptic Vesicle Trafficking Dysfunction Validation in Parki
clinical · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40

See Also (9)

Epigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: expressed_in
ANG — Angiogenin
gene · KG edge: associated_with
ASCL1 Gene
gene · KG edge: regulates
EZH2 — Enhancer of Zeste Homolog 2
gene · KG edge: therapeutic_target
FOXG1 — Forkhead Box G1
gene · KG edge: associated_with

Knowledge Graph (12 edges)

FOXA2 associated_with FOXO6
FOXA2 associated_with FOXO3
FOXA2 associated_with FOXP3
FOXA2 associated_with FOXG1
FOXA2 expressed_in SHH
FOXA2 associated_with FOXP1
FOXA2 associated_with FOXM1
FOXA2 associated_with FOXP4
FOXA2 associated_with FOXO4
FOXA2 associated_with FOXO1

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