gene 611 words KG: E2F2
Contents

E2F Transcription Factor 2

🧬 Gene Info
Gene SymbolE2F2
Full NameE2F Transcription Factor 2
Chromosome1p36.22
Protein TypeGene
Functionis an important component in the neurobiology of neurodegenerative diseases.
Amino Acids404 aa
PathwaysCell Cycle
UniProt IDQ14209
NCBI Gene ID1870
GeneCardsE2F2
Human Protein AtlasE2F2
Official SymbolE2F2
Official NameE2F Transcription Factor 2
G1/S TransitionE2F2 promotes entry into S phase
DNA SynthesisActivates DNA polymerase, cyclin E, and other replication genes
Associated Diseasesneurodegeneration
InteractionsAND, APC, CD8, E2F1, E2F3, E2F4
KG Connections55 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (25)

Circadian Clock-Autophagy Synchronization
Score: 0.76
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78

Related Analyses (23)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (4)

E2F coordination of G2/M transcriptional program
exploratory · proposed · Score: 0.75
E2F regulation of endocycles in hepatocytes
validation · proposed · Score: 0.85
E2F regulation of endocycles in trophoblast giant cells
validation · proposed · Score: 0.85
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (15)

E2F8 Gene
gene · KG edge: activates
E2F4 Gene
gene · KG edge: interacts_with
E2F1 Gene
gene · KG edge: activates
E2F7 Gene
gene · KG edge: activates
Packard Center for ALS Research
institution · KG edge: regulates

Knowledge Graph (12 edges)

E2F7 activates E2F2
E2F8 activates E2F2
E2F1 activates E2F2
E2F2 activates E2F3
E2F2 activates E2F7
E2F2 activates E2F8
TP53 treats E2F2
E2F2 interacts_with E2F4
E2F2 interacts_with RORA
CD8 activates E2F2

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