gene 1,208 words KG: CTSL
Contents

CTSL Gene

🧬 Gene Info
Gene SymbolCTSL
Full NameCathepsin L
Chromosome9q21.33
Protein TypeProtease
Functionencodes a lysosomal cysteine protease that plays crucial roles in protein degradation, antigen processing, and extracellular matrix remodeling.
Primary ExpressionUbiquitous; highest in liver
Amino Acids333 aa
Exons8
PathwaysAutophagy
UniProt IDP07711
NCBI Gene ID1517
Ensembl IDENSG00000135047
OMIM116830
GeneCardsCTSL
Human Protein AtlasCTSL
Associated DiseasesNeurodegeneration, Parkinson
InteractionsACTB, AGING, AIF1, ALZHEIMER, ALZHEIMER'S DISEASE, APOC1
KG Connections137 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (9)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.90
Autophagosome Maturation Checkpoint Control
Score: 0.71
VCP-Mediated Autophagy Enhancement
Score: 0.59
APOE-Dependent Autophagy Restoration
Score: 0.86
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
Piezoelectric Nanochannel BBB Disruption
Score: 0.52

Related Analyses (4)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

Related Experiments (6)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Anti-Tau Antibody vs ASO/Gene Therapy — Comparative Efficacy
validation · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
NLRP3 Inflammasome Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (13)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: implicated_in
BCL2 Gene
gene · KG edge: regulates
BECN1 Gene
gene · KG edge: regulates
BNIP3 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

BNIP3 regulates CTSL
BCL2 regulates CTSL
CTSL therapeutic_target FOXO3
CTSL regulates PIK3R1
CTSL regulates BECN1
CTSL regulates STAT3
CTSL regulates CTSB
CTSL regulates HIF1A
CTSL therapeutic_target FOXO1
CTSL regulates PIK3C3

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