| Gene Symbol | CS |
| Full Name | Citrate Synthase |
| Chromosome | 12p15 |
| Protein Type | Enzyme |
| Function | is a nuclear-encoded gene located on chromosome 12p15 that encodes citrate synthase, a key mitochondrial enzyme that catalyzes the first committed step of the citric acid cycle (TCA cycle). |
| Primary Expression | virtually all tissues with high activity in: - Heart: Highest expression (high energy demand) - Liver: Central metabolic hub - Kidney: Act |
| Amino Acids | 466 aa |
| UniProt ID | O75390 |
| NCBI Gene ID | 1451 |
| Ensembl ID | ENSG00000143228 |
| OMIM | 118950 |
| GeneCards | CS |
| Human Protein Atlas | CS |
| N-terminal domain | Contains the binding site for acetyl-CoA |
| C-terminal domain | Contains the oxaloacetate binding site |
| Associated Diseases | Huntington's disease, neurodegeneration |
| Known Drugs/Compounds | quercetin, rapamycin |
| Interactions | AKT, BDNF, CALCOCO2, CDKN1A, CDKN2A, CXCL1 |
| KG Connections | 48 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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