gene 907 words KG: CLPP
Contents

CLPP (Caseinolytic Mitochondrial Matrix Peptidase Proteolytic)

🧬 Gene Info
Gene SymbolCLPP
Full NameCaseinolytic Mitochondrial Matrix Peptidase Proteolytic Subunit
AliasesCaseinolytic Mitochondrial Matrix Peptidase Proteolytic
Chromosome19p13.3
Protein TypeProtease
Molecular Weight23.4 kDa
Amino Acids473 aa
PathwaysMitochondrial Proteostasis
UniProt ID[Q9NZJ5](https://www.uniprot.org/uniprot/Q9NZJ5)
Ensembl IDENSG00000139289
GeneCardsCLPP
Human Protein AtlasCLPP
Heptad repeat regionsOligomerization domains
Associated DiseasesAging, Als, Ataxia, frontotemporal dementia, Ftd, Ms
InteractionsAkt, AKT, CHCHD2, DNM1L, DRP1, FBXO7
KG Connections235 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (22)

Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
← Prevpg 2/2

Related Analyses (12)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (6)

Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: associated_with
ATM Gene
gene · KG edge: associated_with
BDNF Gene
gene · KG edge: associated_with
C1QA Gene — Complement Component 1q A Chain
gene · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with

Knowledge Graph (12 edges)

ELAVL2 therapeutic_target CLPP
C1Q therapeutic_target CLPP
MTOR therapeutic_target CLPP
CLPP therapeutic_target RAB11
CLPP therapeutic_target STX17
CLPP therapeutic_target RAB5
CLPP therapeutic_target SNAP29
CLPP therapeutic_target IGF2BP1
CLPP therapeutic_target BDNF
CLPP therapeutic_target FUS

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