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gene 907 words KG: CLPP
Contents

CLPP (Caseinolytic Mitochondrial Matrix Peptidase Proteolytic)

🧬 Gene Info
Gene SymbolCLPP
Full NameCaseinolytic Mitochondrial Matrix Peptidase Proteolytic Subunit
AliasesCaseinolytic Mitochondrial Matrix Peptidase Proteolytic
Chromosome19p13.3
Protein TypeProtease
Molecular Weight23.4 kDa
Amino Acids473 aa
PathwaysMitochondrial Proteostasis
UniProt ID[Q9NZJ5](https://www.uniprot.org/uniprot/Q9NZJ5)
Ensembl IDENSG00000139289
GeneCardsCLPP
Human Protein AtlasCLPP
Heptad repeat regionsOligomerization domains
Associated DiseasesAging, Als, Ataxia, frontotemporal dementia, Ftd, Ms
InteractionsAkt, AKT, CHCHD2, DNM1L, DRP1, FBXO7
KG Connections235 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (22)

APOE-Dependent Autophagy Restoration
Score: 0.89AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.83Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Senescent Cell Mitochondrial DNA Release
Score: 0.74Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74SASP-Mediated Complement Cascade Amplification
Score: 0.74TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73Autophagosome Maturation Checkpoint Control
Score: 0.71Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70Mitochondrial Transfer Pathway Enhancement
Score: 0.70Extracellular Matrix Stiffness Modulation
Score: 0.69CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69R-Loop Resolution Enhancement Therapy
Score: 0.68RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67Mitochondrial RNA Granule Rescue Pathway
Score: 0.66Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
pg 1/2Next →

Related Analyses (12)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedPerivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archivedAutophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archivedSenolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (6)

Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: associated_withATM Gene
gene · KG edge: associated_withBDNF Gene
gene · KG edge: associated_withC1QA Gene — Complement Component 1q A Chain
gene · KG edge: associated_withPackard Center for ALS Research
institution · KG edge: associated_with

Knowledge Graph (12 edges)

ELAVL2 therapeutic_target CLPP
C1Q therapeutic_target CLPP
MTOR therapeutic_target CLPP
CLPP therapeutic_target RAB11
CLPP therapeutic_target STX17
CLPP therapeutic_target RAB5
CLPP therapeutic_target SNAP29
CLPP therapeutic_target IGF2BP1
CLPP therapeutic_target BDNF
CLPP therapeutic_target FUS

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