gene 2,387 words KG: CHOP
Contents

CHOP Gene

🧬 Gene Info
Gene SymbolCHOP
Chromosome12q13.12
Protein TypeProtein
Functionis a leucine zipper transcription factor that functions as a critical regulator of cellular stress responses, particularly during endoplasmic reticulum (ER) stress and the unfolded protein response...
PathwaysApoptosis, Epigenetic, Er Stress, Ferroptosis, Glycolysis
UniProt IDSearch UniProt
GeneCardsCHOP
Human Protein AtlasCHOP
Associated DiseasesAD, ALI, Als, Alzheimer, Cancer
Known Drugs/Compoundsrapamycin
InteractionsABCD3, AKT, ALS, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE
KG Connections904 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (29)

Nucleolar Stress Response Normalization
Score: 0.65
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Pharmacological Enhancement of APOE4 Glycosylation
Score: 0.62
Vagal Afferent Microbial Signal Modulation
Score: 0.62
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
VCP-Mediated Autophagy Enhancement
Score: 0.59
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48
Optogenetic Control of Mitochondrial Transfer Networks
Score: 0.48
← Prevpg 2/2

Related Analyses (18)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Proposed experiment from debate on TDP-43 undergoes liquid-l
falsification · proposed · Score: 0.40

See Also (10)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: biomarker_for
ABCD3 Gene
gene · KG edge: interacts_with
ALDH1L1
gene · KG edge: expressed_in
AMBRA1 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

CHOP regulates BECLIN1
OPTN interacts_with CHOP
DNM1L interacts_with CHOP
LGALS3 interacts_with CHOP
CALCOCO2 interacts_with CHOP
G3BP1 interacts_with CHOP
PEX3 interacts_with CHOP
SQSTM1 interacts_with CHOP
BCL2 interacts_with CHOP
LMNA interacts_with CHOP

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