gene 2,339 words KG: CELF2
Contents

CELF2 Gene

🧬 Gene Info
Gene SymbolCELF2
Full NameCUGBP Elav-Like Family Member 2
Chromosome10p21.3
Functionis a member of the CELF family of RNA-binding proteins that plays critical roles in post-transcriptional gene regulation.
Primary Expressionthe brain with particularly high levels in the cerebral cortex, hippocampus, and cerebellum, where it regulates alternative splicing, mRNA translation
Molecular Weight57 kDa
Amino Acids512 aa
UniProt IDO95393
NCBI Gene ID10689
Ensembl IDENSG00000149532
OMIM601128
GeneCardsCELF2
Human Protein AtlasCELF2
Associated DiseasesAlzheimer's disease, ALS
InteractionsNOVA2, SFPQ
KG Connections28 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (9)

Cryptic Exon Silencing Restoration
Score: 0.53
CYP46A1 Overexpression Gene Therapy
Score: 0.95
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
VCP-Mediated Autophagy Enhancement
Score: 0.59
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47

Related Analyses (5)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: expressed_in
CTNNB1 — Catenin Beta 1
gene · KG edge: expressed_in
EGFR — Epidermal Growth Factor Receptor
gene · KG edge: expressed_in
FYN — FYN Proto-Oncogene, Src Family Tyrosine Kinase
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

FYN expressed_in CELF2
VCP expressed_in CELF2
CTNNB1 expressed_in CELF2
EGFR expressed_in CELF2
HSP90AA1 expressed_in CELF2
APP expressed_in CELF2
HSP90AB1 expressed_in CELF2
MDM2 expressed_in CELF2
HSF1 expressed_in CELF2
GRB2 expressed_in CELF2

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