gene

NOVA2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NOVA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections

0Hypotheses

0Analyses

1Outgoing

1Incoming

0Experiments

0Debates

Summary

Page for NOVA2 — NOVA Alternative Splicing Regulator 2

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🧬 Gene Info

Gene Symbol	NOVA2
Full Name	NOVA Alternative Splicing Regulator 2
Chromosome	19p13.3
Function	encodes a neuron-specific KH-type RNA-binding protein on chromosome 19p13.
Primary Expression	Neurons (neocortex, hippocampus), Vascular endothelium
Amino Acids	492 aa
Exons	8
Pathways	Bdnf exon I-IX splicing
UniProt ID	Q9UNW9
NCBI Gene ID	4858
Ensembl ID	ENSG00000104967
OMIM	601991
GeneCards	NOVA2
Human Protein Atlas	NOVA2
KH1, KH2, KH3 domains	Each adopts a βααββα fold; KH3 is the primary RNA-recognition domain, directly contacting YCAY tetranucleotide motifs with high specificity
Associated Diseases	Alzheimer's Disease, Huntington's Disease, Epilepsy
Interactions	CELF2
KG Connections	2 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NOVA2 — AlphaFold Q9UNW9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NOVA2 — NOVA Alternative Splicing Regulator 2

gene · 1403 words

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Pathway Diagram

flowchart TD
    N0["NOVA2"]
    N1["Bdnf exon I-IX splicing"]
    N0 -->|"regulates"| N1
    N2["neurodegeneration"]
    N0 -->|"implicated in"| N2

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 pathway

Outgoing (1)

Target	Relation	Type	Str
Bdnf exon I-IX splicing	regulates	pathway	0.80

Incoming (1)

Source	Relation	Type	Str
CELF2	interacts_with	protein	0.92

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NOVA2 in their description or question text

No additional research found