gene 2,828 words KG: CD2AP
Contents

CD2AP Gene — CD2-Associated Protein

🧬 Gene Info
Gene SymbolCD2AP
Full NameCD2-Associated Protein
Chromosome6p12.3
Protein FamilySH3 domain-containing adaptor proteins
Functionis a scaffolding protein that plays critical roles in immune cell signaling, cytoskeletal organization, and receptor trafficking.
Primary Expressionthe brain, pa
Molecular Weight70 kDa
Amino Acids639 aa
Exons13
Gene TypeProtein coding
PathwaysEndocytosis
UniProt IDQ9Y5K7
NCBI Gene ID9501
Ensembl IDENSG00000198034
OMIM604332
GeneCardsCD2AP
Human Protein AtlasCD2AP
Associated DiseasesAD, ALI, Als, Alzheimer, Alzheimer's disease
InteractionsABCA1, ABCA7, Actin, AD, ALZHEIMER, ALZHEIMER DISEASE
KG Connections484 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (23)

LRP1-Dependent Tau Uptake Disruption
Score: 0.60
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
TREM2-Dependent Microglial Senescence Transition
Score: 0.58
← Prevpg 2/2

Related Analyses (13)

Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (10)

Endothelial CD2AP knockdown effects on memory in male mice
validation · proposed · Score: 0.90
CD2AP downregulation in brain endothelial cells - memory fun
validation · proposed · Score: 0.90
Reelin glycoprotein treatment rescue experiment
validation · proposed · Score: 0.90
Cerebrovascular function analysis in CD2AP mutant mice
validation · proposed · Score: 0.90
Cerebral blood flow regulation in CD2AP mutant mice
validation · proposed · Score: 0.88

See Also (7)

ABCA7 (Redirect)
redirect · KG edge: activates
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_with
ABI3 Gene
gene · KG edge: associated_with
ACE Gene
gene · KG edge: associated_with
adam17
gene · KG edge: associated_with

Knowledge Graph (12 edges)

REST activates CD2AP
CD2AP activates REELIN
CD2AP activates REST
CD2AP expressed_in neuron
CD2AP regulates tau pathology
CD2AP implicated_in vascular dysfunction
CD2AP causes Cerebrovascular Dysfunction
CD2AP expressed_in Endothelial Cells
CD2AP regulates Blood-Brain Barrier Function
CD2AP involved_in Cerebrovascular Function

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