CD2AP expression and cognitive decline in AD patients

Exploratory Score: 0.800 Price: $0.50 Alzheimer's disease human patients Status: proposed

What This Experiment Tests

Exploratory experiment designed to discover new patterns targeting CD2AP in human patients. Primary outcome: association between vascular CD2AP loss and cognitive decline

Description

Analysis of CD2AP expression levels in cerebral blood vessels from Alzheimer's disease subjects to examine the association between loss of vascular CD2AP and cognitive decline. The study examined post-mortem brain tissue from AD patients to determine whether reduced CD2AP levels in brain vasculature correlate with cognitive impairment measures.

TARGET GENE

CD2AP

MODEL SYSTEM

human patients

ESTIMATED COST

$0

TIMELINE

0 months

PATHWAY

cerebrovascular function

SOURCE

extracted_from_pmid_39892386

PRIMARY OUTCOME

association between vascular CD2AP loss and cognitive decline

Scoring Dimensions

📖 Wiki Pages

CD2AP Synaptic Dysfunction Alzheimer's Disease Caumechanism CD2AP Proteinprotein CD2AP Gene — CD2-Associated Proteingene Alzheimer's Diseasedisease Alzheimer's Disease Genetic Variantsdisease Alzheimer's Disease vs Parkinson's Disease Comparidisease APP Mutations in Alzheimer's Diseasedisease DLB, Parkinson's Disease, and Alzheimer's Disease:disease Early-Onset Alzheimer's Disease (EOAD)disease Investment Landscape: Alzheimer's Diseasedisease Prodromal Alzheimer's Diseasedisease PSEN1 Mutations in Alzheimer's Diseasedisease PSEN2 Mutations in Alzheimer's Diseasedisease Sporadic vs Familial Alzheimer's Disease: Comprehedisease TREM2 Variants in Alzheimer's Diseasedisease

Protocol

analysis of CD2AP expression in cerebral blood vessels from AD patient brain tissue

Expected Outcomes

reduced CD2AP expression associated with cognitive decline

Success Criteria

significant correlation between CD2AP loss and cognitive measures

Related Hypotheses (5)

APOE Isoform Expression Across Glial Subtypes0.743

TREM2-mediated microglial tau clearance enhancement0.618

LRP1-Dependent Tau Uptake Disruption0.600

OPC differentiation blockade contributes to white matter degeneration in early-stage AD0.599

Extracellular Vesicle Biogenesis Modulation0.582

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