Validation experiment designed to validate causal mechanisms targeting CD2AP in mice. Primary outcome: restoration of cerebral blood flow and protection against Aβ toxicity
Treatment of CD2AP mutant mice with reelin glycoprotein to test whether this intervention could mitigate the effects of CD2AP loss of function via ApoER2 signaling. The experiment examined whether reelin treatment could restore cerebrovascular function and protect against amyloid-β toxicity. Results showed increased resting cerebral blood flow and protection of male mice against amyloid-β effects, demonstrating the therapeutic potential of reelin in addressing CD2AP-related vascular dysfunction.
reelin glycoprotein treatment, measurement of cerebral blood flow, amyloid-β challenge
increased cerebral blood flow and protection against amyloid-β in male mice
significant improvement in blood flow and reduced amyloid-β toxicity
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