gene 726 words KG: CACNA1I
Contents

CACNA1I Gene - Calcium Voltage-Gated Channel Subunit Alpha1 I

🧬 Gene Info
Gene SymbolCACNA1I
Full NameCACNA1I - Calcium Voltage-Gated Channel Subunit Alpha1 I
AliasesPage for CACNA1I Gene, Page for CACNA1I Protein
Chromosome22q12.3
Protein TypeGene
FunctionCav3.3 (T-type) calcium channels are crucial for
Amino Acids226 aa
GeneCardsCACNA1I
Human Protein AtlasCACNA1I
Neuronal rhythmicityGenerate low-threshold calcium spikes in thalamic and cortical neurons
Thalamic oscillationsCritical for sleep spindles and absence seizures
Dendritic integrationMediate back-propagation of calcium signals
Gene expressionActivate calcium-dependent signaling cascades
Associated Diseasesneurodegeneration
InteractionsCACNA1A, CACNA1C, CACNA1D, CACNA1E, cacna1f, CACNA1F
KG Connections38 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (8)

CYP46A1 Overexpression Gene Therapy
Score: 0.73
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56

Related Analyses (8)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

See Also (12)

Neurodegeneration
disease · KG edge: implicated_in
Genes
index · KG edge: associated_with
CACNA1A — Calcium Channel Alpha-1A Subunit
gene · KG edge: associated_with
CACNA1C Gene
gene · KG edge: associated_with
CACNA1D Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CACNA1A associated_with CACNA1I
CCS contributes_to CACNA1I
CACNA1C associated_with CACNA1I
CACNA2D2 associated_with CACNA1I
CACNA1F associated_with CACNA1I
CACNA1I associated_with CACNA2D1
CACNA1I associated_with CACNA1E
CACNA1I associated_with CACNA1H
CACNA1I associated_with CACNA1D
CACNA1I associated_with CACNA1G

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