concept

ESM1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ESM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections

0Hypotheses

0Analyses

22Outgoing

7Incoming

0Experiments

0Debates

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💡 Concept Info

Name	ESM1
Key Genes/Proteins	ADAMTS1, BECN1, CAV1, HIF-1α, HPSE, ICAM1
Related Diseases	Idiopathic Nephrotic Syndrome
Related Pathways	autophagy pathway, lipid metabolism

Pathway Diagram

graph TD
    ESM1[ESM1]
    ESM1 -->|regulates| BECN1[BECN1]
    ESM1 -->|interacts| PKM2[PKM2]
    ESM1 -->|downregulates| Idiopathic_Nephrotic_Syndrome[Idiopathic Nephrotic Syndrome]
    ESM1 -.protects against.-> endothelial_homeostasis[endothelial homeostasis]
    ESM1 -->|expressed in| endothelial_cells[endothelial cells]
    ESM1 -->|regulates| IGF2BP3[IGF2BP3]
    ESM1 -->|activates| HPSE[HPSE]
    ESM1 -->|activates| ICAM1[ICAM1]
    ESM1 -->|activates| MMP2[MMP2]
    ESM1 -->|activates| MMP9[MMP9]
    HIF_1_[HIF-1α] -->|regulates| ESM1
    IGF2BP3 -->|regulates| ESM1
    BECN1 -->|regulates| ESM1
    ADAMTS1[ADAMTS1] -->|activates| ESM1
    CAV1[CAV1] -->|activates| ESM1
    benchmark_ot_ad_answer_key_ESM[benchmark_ot_ad_answer_key:ESM1] -->|data_in| ESM1

Outgoing (22)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ESM1	data_in	dataset_row	0.00
BECN1	regulates	protein	0.95
ovarian cancer	associated_with	disease	0.92
PKM2	interacts_with	protein	0.90
Idiopathic Nephrotic Syndrome	downregulates	disease	0.75
endothelial cells	expressed_in	cell_type	0.70
endothelial homeostasis	protects_against	process	0.70
lipid metabolism	participates_in	pathway	0.60
INS	associated_with	gene	0.60
INS	regulates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
HPSE	activates	gene	0.60
ICAM1	activates	gene	0.60
MMP2	activates	gene	0.60
MMP9	activates	gene	0.60
NOS3	activates	gene	0.60
MMP9	regulates	gene	0.60
HPSE	associated_with	gene	0.60
ICAM1	associated_with	gene	0.60
MMP2	associated_with	gene	0.60
NOS3	associated_with	gene	0.60
IGF2BP3	regulates	gene	0.60

Incoming (7)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ESM1	data_in	dataset_row	0.00
HIF-1α	regulates	gene	0.95
IGF2BP3	regulates	protein	0.90
BECN1	regulates	gene	0.60
BECN1	inhibits	gene	0.60
ADAMTS1	activates	gene	0.60
CAV1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ESM1 in their description or question text

No additional research found