Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HPSE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | HPSE |
| Key Genes/Proteins | ADAMTS1, CAV1, ESM1, ICAM1, INS, MMP2 |
| Related Diseases | kidney function |
| Related Pathways | oxidative stress response |
graph TD
HPSE[HPSE]
HPSE -->|degrades| Glycocalyx[Glycocalyx]
HPSE -->|regulates| glomerular_endothelial_glycoca[glomerular endothelial glycocalyx]
HPSE -->|downregulates| kidney_function[kidney function]
HPSE -->|activates| ICAM1[ICAM1]
HPSE -->|activates| MMP2[MMP2]
HPSE -->|activates| MMP9[MMP9]
HPSE -->|activates| NOS3[NOS3]
ADAMTS1[ADAMTS1] -->|activates| HPSE
CAV1[CAV1] -->|activates| HPSE
ESM1[ESM1] -->|activates| HPSE| Target | Relation | Type | Str |
|---|---|---|---|
| Glycocalyx | degrades | biomarker | 0.95 |
| glomerular endothelial glycocalyx | regulates | process | 0.90 |
| kidney function | associated_with | phenotype | 0.85 |
| glomerular endothelial glycocalyx | degrades | process | 0.85 |
| kidney function | downregulates | phenotype | 0.80 |
| endothelial cells | expressed_in | cell_type | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| INS | associated_with | gene | 0.60 |
| ICAM1 | activates | gene | 0.60 |
| MMP2 | activates | gene | 0.60 |
| MMP9 | activates | gene | 0.60 |
| NOS3 | activates | gene | 0.60 |
| ICAM1 | interacts_with | gene | 0.60 |
| NOS3 | interacts_with | gene | 0.60 |
| MMP2 | interacts_with | gene | 0.60 |
| ICAM1 | associated_with | gene | 0.60 |
| MMP2 | associated_with | gene | 0.60 |
| NOS3 | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning HPSE in their description or question text
No additional research found