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entity 1,004 words KG: NMDA
Contents

NMDA Receptor

🔬 Protein Info
Gene SymbolNMDA
AliasesGRIN2B, GRIN1
Molecular Weight166 kDa
Pathwaysglutamate signaling, unfolded protein response, oxidative stress response, mitochondrial function, sphingolipid metabolism
GeneCardsNMDA
Human Protein AtlasNMDA
Associated DiseasesALS, Alzheimer, Alzheimer'S Disease, disease, epilepsy, Huntington
Known Drugs/Compoundsmemantine
InteractionsABCA7, AMPA RECEPTOR, AMYLOID, APP, ATP, BAK
KG Connections211 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

Wikipedia

Related Hypotheses (34)

Competitive APOE4 Domain Stabilization Peptides
Score: 0.78Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76Senescence-Activated NAD+ Depletion Rescue
Score: 0.76CYP46A1 Overexpression Gene Therapy
Score: 0.73Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.67Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67Microbial Inflammasome Priming Prevention
Score: 0.65APOE-Mediated Synaptic Lipid Raft Stabilization
Score: 0.65Transglutaminase-2 Cross-Linking Inhibition Strategy
Score: 0.64Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54
← Prevpg 2/2

Related Analyses (22)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archivedEpigenetic reprogramming in aging neurons
neurodegeneration · archivedTau propagation mechanisms and therapeutic interception poin
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (4)

Ketamine in pediatric TRD patients
clinical · proposed · Score: 0.70Ketamine in obstetric TRD patients
clinical · proposed · Score: 0.70Ketamine efficacy in geriatric TRD patients
clinical · proposed · Score: 0.70Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40

See Also (10)

GABA (Gamma-Aminobutyric Acid) - Neurodegenerative Dise
biomarker · KG edge: inhibitsNeurodegeneration
disease · KG edge: co_discussedAmyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activatesglutamate
general · KG edge: activatesLong-Term Potentiation (LTP)
entity · KG edge: inhibits

Knowledge Graph (12 edges)

Memantine activates NMDA
Memantine inhibits NMDA
GLUTAMATE co_discussed NMDA
ALZHEIMER co_discussed NMDA
ALZHEIMER'S co_discussed NMDA
NEURODEGENERATION co_discussed NMDA
NEURONS co_discussed NMDA
AMYLOID activates NMDA
GENES co_discussed NMDA
NMDA activates P2Y12

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