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biomarker 1,499 words KG: GLUTAMATE
Contents

Glutamate - Excitotoxicity and Neurodegeneration Biomarker

🔬 Protein Info
Gene SymbolGLUTAMATE
Complementary to protein biomarkersGlutamate provides orthogonal information to Aβ (A) and tau (T) markers
Network dysfunction assessmentCaptures hyperexcitability not reflected in structural biomarkers
Therapeutic monitoringAnti-excitotoxic treatments should show glutamate normalization
Prognostic valueElevated glutamate predicts progression in AD, PD, and ALS
Associated DiseasesCOGNITIVE DECLINE, EPILEPSY, EXCITOTOXICITY, FERROPTOSIS, GLUTAMATE EXCITOTOXICITY, GLYCOLYSIS
Known Drugs/CompoundsKETAMINE
InteractionsAKT, AMPK, APOE, APP, BIN1, PARKIN
KG Connections616 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (30)

Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.92CYP46A1 Overexpression Gene Therapy
Score: 0.92SASP-Mediated Complement Cascade Amplification
Score: 0.91Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91Transcriptional Autophagy-Lysosome Coupling
Score: 0.88

Related Analyses (30)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archivedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (30)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40Proposed experiment from debate on Epigenetic clocks and bio
falsification · proposed · Score: 0.40Proposed experiment from debate on Microglia activate astroc
falsification · proposed · Score: 0.40Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · proposed · Score: 0.40

See Also (15)

Beta-Propeller Protein-Associated Neurodegeneration (BP
disease · Pages share 139 hypothesesChina Neurodegeneration Epidemiology
disease · Pages share 139 hypothesesNeuroimaging for Parkinsonian Syndromes (NCT03872102)
clinical · Pages share 27 hypothesesSynaptic Biomarkers in Neurodegeneration
biomarker · Pages share 139 hypothesesOlfactory Mucosa, Blood and Urine for Identification of
clinical · Pages share 139 hypotheses

Knowledge Graph (12 edges)

MACROPHAGES activates GLUTAMATE
GLUTAMATE inhibits AXONS
GLUTAMATE causes EXCITOTOXICITY
FERROPTOSIS co_discussed GLUTAMATE
GLUTAMATE co_discussed GPX4
GLUTAMATE co_discussed MITOCHONDRIA
BRAINSTEM co_discussed GLUTAMATE
FOXO3 co_discussed GLUTAMATE
GLUTAMATE co_discussed OPTN
GLUTAMATE co_discussed PINK1

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