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general 2,389 words KG: GLUTAMATE
Contents

glutamate

🔬 Protein Info
Gene SymbolGLUTAMATE
Associated DiseasesCOGNITIVE DECLINE, EPILEPSY, EXCITOTOXICITY, FERROPTOSIS, GLUTAMATE EXCITOTOXICITY, GLYCOLYSIS
Known Drugs/CompoundsKETAMINE
InteractionsAKT, AMPK, APOE, APP, BIN1, PARKIN
KG Connections610 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (30)

AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.81Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76Epigenetic Memory Erasure via TET2 Activation
Score: 0.74Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73Adenosine-Astrocyte Metabolic Reset
Score: 0.73

Related Analyses (28)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedSynaptic pruning by microglia in early AD
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedEpigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

Related Experiments (8)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40Stress-induced depression model sleep architecture analysis
validation · proposed · Score: 0.90Electrophysiological analysis of mPFC-vlPAG synaptic transmi
exploratory · proposed · Score: 0.85Pathway analysis of aminophylline effects on neuronal signal
exploratory · proposed · Score: 0.70s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40

See Also (5)

acetylcholine
general · KG edge: co_discussedadra2b Gene
gene · KG edge: expressed_inGPX4 Gene - Glutathione Peroxidase 4
gene · KG edge: co_discussedAlzheimer Indonesia
institution · KG edge: activatesPackard Center for ALS Research
institution · KG edge: associated_with

Knowledge Graph (12 edges)

GLUTAMATE associated_with EXCITOTOXICITY
MACROPHAGES activates GLUTAMATE
GLUTAMATE inhibits AXONS
GLUTAMATE causes EXCITOTOXICITY
FERROPTOSIS co_discussed GLUTAMATE
GLUTAMATE co_discussed GPX4
GLUTAMATE co_discussed MITOCHONDRIA
BRAINSTEM co_discussed GLUTAMATE
FOXO3 co_discussed GLUTAMATE
GLUTAMATE co_discussed OPTN

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