biomarker 1,507 words KG: GABA
Contents

GABA (Gamma-Aminobutyric Acid) - Neurodegenerative Disease Biomarker

🔬 Protein Info
Gene SymbolGABA
Chromosome12p12.3
Functionis a hallmark of neurodegeneration.
Primary Expressionhippocampus, cortex, cerebellum, thalamus, hypothalamus
Amino Acids602 aa
Exons14
PathwaysGABAergic Signaling
GeneCardsGABA
Human Protein AtlasGABA
GABA_A receptorsLigand-gated chloride channels mediating fast inhibitory signaling
GABA_B receptorsG-protein coupled receptors mediating slow, prolonged inhibition
Associated DiseasesAls, Alzheimer, Alzheimer's disease
Known Drugs/Compoundsrapamycin
InteractionsABCA7, ACTB, Actin, Akt, AKT, AKT1
KG Connections1370 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (38)

Orexin-Microglia Modulation Therapy
Score: 0.71
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.69
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69
...
Score: 0.68
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68
Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.67
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
HCN1-Mediated Resonance Frequency Stabilization Therapy
Score: 0.65
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Restoring Neuroprotective Tryptophan Metabolism via Targeted
Score: 0.61
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor
Score: 0.53
Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption
Score: 0.47
Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43
← Prevpg 2/2

Related Analyses (30)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived

Related Experiments (19)

Experiment Validation: In vitro ThT Assay
validation · proposed · Score: 0.40
Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.40
Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40
Regulated Necrosis Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (8)

acetylcholine
general · KG edge: co_discussed
ACTB Gene
gene · KG edge: associated_with
adra2b Gene
gene · KG edge: expressed_in
AKT1 Gene
gene · KG edge: interacts_with
Gene Page: ALS4 (SENATAXIN)
gene · KG edge: activates

Knowledge Graph (12 edges)

GABA associated_with MTOR
GABA associated_with TFEB
AKT associated_with GABA
BACE1 associated_with GABA
TAU associated_with GABA
GABA associated_with neuroinflammation
GABA associated_with serotonin
GABA associated_with GABAergic neurons
GABA interacts_with GABARAP
FLCN interacts_with GABA

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