gene 2,364 words KG: ATF6
Contents

ATF6 - Activating Transcription Factor 6

🧬 Gene Info
Gene SymbolATF6
Full NameActivating Transcription Factor 6
Chromosome1q22.1
Functionis a Type II transmembrane protein that serves as a critical endoplasmic reticulum (ER) stress sensor and transcriptional activator.
Molecular Weight90 kDa
PathwaysAkt, Autophagy, Lipid Metabolism, Mapk, Mtor
UniProt ID[Q09470](https://www.uniprot.org/uniprot/Q09470)
Ensembl IDENSG00000118260
OMIM604436
GeneCardsATF6
Human Protein AtlasATF6
Associated DiseasesAls, Alzheimer, Autoimmune, Cancer, Carcinoma, Diabetes
Known Drugs/Compoundsrapamycin
InteractionsAKT, AKT1, AKT1S1, ALZHEIMER'S DISEASE, AMPK, AMYOTROPHIC LATERAL SCLEROSIS
KG Connections425 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (1)

Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72

Related Analyses (1)

Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived

Knowledge Graph (12 edges)

ATF6 interacts_with MLKL
ATF6 interacts_with DEPTOR
ATF6 interacts_with HMGB1
ATF6 interacts_with EGF
ATF6 interacts_with MLST8
ATF6 interacts_with RICTOR
ATF6 interacts_with MTOR
ATF6 interacts_with PIK3C3
ATF6 interacts_with EGFR
ATF6 interacts_with PPARG

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.