SIRT1

NAD-dependent protein deacetylase sirtuin-1

Score: 0.463 Price: $0.46 Medium Druggability Status: active Wiki: SIRT1 Gene

HYPOTHESES

PAPERS

KG EDGES

DEBATES

3D Protein Structure

🧬 SIRT1 — PDB 4KXQ Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Druggability & Clinical Context

Druggability

Medium

Score: 0.48

Clinical Stage

Phase III

Target Class

Epigenetic Regulator

Safety

0.73

Druggability Analysis

Drug Development0.45

Structural Tractability0.70

Target Class0.70

Safety Profile0.73

Key Metrics

PDB Structures:

Known Drugs:

Approved:

In Clinical Trials:

Drug Pipeline (3 compounds)

Mechanism: SIRT1 activation via NAD+ precursors or allosteric activators deacetylates tau (reducing aggregation), enhances mitophagy, and restores circadian gene expression

Drug Pipeline (3 compounds)

Known Drugs:

NMN (Clinical Trials)

Resveratrol (Clinical Trials)

SRT2104 (Phase 2)

Structural Data:

PDB (5) ✓AlphaFold ✓Cryo-EM —

4KXQ 5BTR 4IG9 4ZZH 5BTR

UniProt: Q96EB6

🧬 3D Protein Structure

🧬 SIRT1 — PDB 4KXQ Click to expand interactive 3D viewer

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

3D Protein Structure

PDB: Open in RCSB AlphaFold model

Interactive 3D viewer powered by RCSB PDB / Mol*. Use mouse to rotate, scroll to zoom.

Clinical Trials (6)

Relevant trials from ClinicalTrials.gov

Active

Completed

Total Enrollment

313

By Phase

PHASE1: 1 · PHASE2: 3 · PHASE3: 2

Evaluation of the Anti-Plaque Effect of a Resveratrol-Based Mouthwash Using a 24-Hour Plaque Re-Growth Not Yet Recruiting

PHASE3 NCT07393802 n=20

Mouthwash, Chlorhexidine, Biofilm Formation

Interventions: Resveratrol-Based Mouthwash, Chlorhexidine Gluconate 0.12 % Mouthwash, Placebo mouthwash

Sponsor: University of Baghdad | Started: 2026-03

Evaluation of the Beneficial Effects of a Nasal Spray of Resveratrol in Children With Seasonal Allergic Rhinitis Completed

PHASE3 NCT02130440 n=100

Seasonal Allergic Rhinitis

Interventions: Resveratrol nasal spray

Sponsor: University of Campania Luigi Vanvitelli | Started: 2012-11

Effect of Resveratrol Administration on Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion Completed

PHASE2 NCT02114892 n=24

Metabolic Syndrome X

Interventions: Resveratrol, Placebo

Sponsor: University of Guadalajara | Started: 2012-04

Study of the Clinical Activity, Safety, and Tolerability of SRT2104 in Subjects With Moderate to Severe Plaque-Type Psor Completed

PHASE2 NCT01154101 n=40

Psoriasis

Interventions: Placebo, SRT2104

Sponsor: Sirtris, a GSK Company | Started: 2010-06-07

A Clinical Study to Assess the Safety, Tolerability, and Activity of Oral SRT2104 Capsules Administered for 28 Days to S Completed

PHASE2 NCT01018017 n=86

Diabetes Mellitus, Type 2

Interventions: Placebo, SRT2104

Sponsor: GlaxoSmithKline | Started: 2010-03-03

A Clinical Study to Assess the Safety and Pharmacokinetics of SRT2104 in Normal Healthy Male Volunteers Completed

PHASE1 NCT00933530 n=43

Diabetes Mellitus, Type 2, Healthy Volunteer

Interventions: SRT2104, Placebo

Sponsor: Sirtris, a GSK Company | Started: 2008-05

Linked Hypotheses (3)

Nutrient-Sensing Epigenetic Circuit Reactivation0.907

SIRT1-Mediated Reversal of TREM2-Dependent Microglial Senescence0.895

Astrocyte Metabolic Memory Reprogramming0.646

Linked Experiments (0)

No linked experiments

Scoring Dimensions

Knowledge Graph (20)

activates (1)

SIRT1→BDNF

associated with (18)

OPTN→SIRT1ULK1→SIRT1CALCOCO2→SIRT1HSPA8→SIRT1STX17→SIRT1

▸ Show 13 more

SQSTM1→SIRT1KAT8→SIRT1RB1CC1→SIRT1SIRT1→LC3SIRT1→SNAP29SIRT1→RB1SIRT1→KAT2BSIRT1→KAT5SIRT1→WIPI2SIRT1→BECN1SIRT1→HDAC6SIRT1→CREBBPSIRT1→NBR1

regulates (1)

SIRT1→CELLULAR_METABOLISM

Debate History (1)

Should SIRT1 (NAD-dependent protein deacetylase sirtuin-1) be prioritized as a t2026-04-22