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What are the downstream signaling pathways linking ARF6/exocyst to VE-cadherin trafficking?

OPEN

While ARF6 and exocyst complex are identified as VE-cadherin interactors involved in trafficking and recycling, the specific signaling cascades and regulatory mechanisms remain undefined. This limits understanding of how junctional remodeling is precisely controlled. Gap type: unexplained_observation Source paper: Proximity interactome of lymphatic VE-cadherin reveals mechanisms of junctional remodeling and reelin secretion. (2024, Nat Commun, PMID:39232006)

Priority: 0.56 Domain: cell biology Hypotheses: 0
📊 Landscape Analysis

Landscape Summary: What are the downstream signaling pathways linking ARF6/exocyst to VE-cadherin trafficking? is a 0.56 priority gap in cell biology. It has 0 linked hypotheses with average composite score 0.000. Status: open.

Key Unanswered Questions

Key Researchers

Colonna, Sevlever, et al. (TREM2 biology)

Clinical Trials

What are the downstream signaling pathways linking ARF6/exocyst to VE-cadherin trafficking? — INVOKE-2 (completed)

📈 Living Dashboards
0
Hypotheses
0.000
Top Score
0.000
Avg Score
0
Debates
0.00
Avg Quality
0%
Resolution
0
Mechanistic Families
Gap Resolution Progress0%

Hypothesis Score Distribution

🏆 Competing Hypotheses (Ranked by Score)

No hypotheses linked to this gap yet.

🌊 Knowledge Graph Connections

activates (5)

ARF6→ATGARF6→DCTN1ARF6→LAMP2ARF6→LC3BARF6→MAP1LC3B

associated with (7)

ARF6→AlsARF6→ALSARF6→RAB11ARF6→APPARF6→RAC1
▸ Show 2 more

expressed in (1)

ARF6→neurons

inhibits (5)

ARF6→AlzheimerARF6→AMYLOIDARF6→ALZHEIMERARF6→ENDOSOMESARF6→AMYLOID-BETA

interacts with (10)

Exocyst Complex→VE-cadherinARF6→CDH5ARF6→VE-cadherinVE-cadherin→Exocyst ComplexVE-cadherin→ARF6
▸ Show 5 more

involved in (5)

ARF6→Cdh5 TraffickingVE-cadherin→VE-cadherin TraffickingARF6→Ve-Cadherin TraffickingARF6→junctional remodelingARF6→VE-cadherin Trafficking

mediates (1)

VE-cadherin→Adherens Junction Remodeling

modulates (2)

VE-cadherin→Lymphatic PermeabilityVE-cadherin→Cytoskeletal Remodeling

participates in (3)

VE-cadherin→exocyst complexVE-cadherin→ARF6ARF6→autophagy pathway

regulates (11)

TMEM16F→VE-cadherinVE-cadherin→reelin secretionVE-cadherin→Reelin SecretionARF6→CDH5ARF6→VE-cadherin trafficking
▸ Show 6 more
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