Contents

LC3B Protein

🔬 Protein Info

Gene Symbol	LC3B
Aliases	LC3BPROTEIN
Chromosome	16q24.2.
Subcellular Localization	</strong></td><td>Cytoplasm, Autophagosome membrane</td></tr>
Pathways	Amyloid Beta Clearance
GeneCards	LC3B
Human Protein Atlas	LC3B
Ubiquitin-like domain	Structural similarity to ubiquitin
LC3-interacting region (LIR)	Docking site for autophagy receptors
Hydrophobic pocket	Accepts PE conjugation
N-terminal arm	Involved in membrane recruitment
LC3-I	Cytosolic, unconjugated (molecular weight ~17 kDa)
LC3-II	Membrane-bound, PE-conjugated (molecular weight ~16 kDa)
Autophagosome formation	Essential for nucleation and expansion
Cargo recognition	Recruits selective autophagy receptors
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	curcumin, rapamycin
Interactions	ABCA1, ABCD3, ACHE, ACSL4, ACTB, AGING
KG Connections	1760 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

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