Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about UBE3A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
UBE3A is a gene implicated in neurodegeneration research. Key relationships include: regulates, contributes to, implicated in. Associated with Inflammation, Ms, Neuroinflammation. Connected to 23 entities in the SciDEX knowledge graph.
No AI portrait yet
| Gene Symbol | UBE3A |
| Full Name | Ubiquitin Protein Ligase E3A |
| Chromosome | 15q11.2 |
| Primary Expression | Brain (neurons), widespread peripheral tissue |
| Subcellular Localization | **HECT domain** — the catalytic domain (~350 aa) that transfers ubiquitin to substrates |
| Molecular Weight | 100 kDa |
| Amino Acids | 865 aa |
| Pathways | Er Stress, Innate Immunity, Mitophagy |
| UniProt ID | Q05086 |
| NCBI Gene ID | 7332 |
| Ensembl ID | ENSG00000114062 |
| OMIM | 601623 |
| GeneCards | UBE3A |
| Human Protein Atlas | UBE3A |
| Associated Diseases | neurodegeneration |
| KG Connections | 28 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
UBE3A["UBE3A"]
Parkinson{"Parkinson"}
UBE3A -->|"regulates"| Parkinson
Ms{"Ms"}
UBE3A -->|"regulates"| Ms
Neuroinflammation{"Neuroinflammation"}
UBE3A -->|"regulates"| Neuroinflammation
Inflammation{"Inflammation"}
UBE3A -->|"regulates"| Inflammation
CREB3["CREB3"]
UBE3A -->|"contributes to"| CREB3
ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
UBE3A -->|"regulates"| ALPHA_SYNUCLEIN
PARKIN["PARKIN"]
UBE3A -->|"regulates"| PARKIN
UBIQUITIN["UBIQUITIN"]
UBE3A -->|"regulates"| UBIQUITIN
PARK6["PARK6"]
UBE3A -->|"regulates"| PARK6
MITOPHAGY["MITOPHAGY"]
UBE3A -->|"regulates"| MITOPHAGY
MAPK8["MAPK8"]
UBE3A -->|"contributes to"| MAPK8
ASTROCYTES["ASTROCYTES"]
UBE3A -->|"regulates"| ASTROCYTES
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
PARKINSON_S_DISEASE -->|"regulates"| UBE3A
MICROGLIA["MICROGLIA"]
MICROGLIA -->|"regulates"| UBE3A
style UBE3A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Parkinson | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Neuroinflammation | regulates | disease | 0.65 |
| Inflammation | regulates | disease | 0.65 |
| Er Stress | regulates | pathway | 0.60 |
| Innate Immunity | regulates | pathway | 0.60 |
| Mitophagy | regulates | pathway | 0.60 |
| ALPHA-SYNUCLEIN | regulates | gene | 0.60 |
| Mapk | contributes_to | pathway | 0.60 |
| MITOPHAGY | regulates | gene | 0.60 |
| ASTROCYTES | regulates | gene | 0.60 |
| NEUROINFLAMMATION | regulates | gene | 0.60 |
| VCP | regulates | gene | 0.60 |
| CREB3 | contributes_to | gene | 0.60 |
| PARKIN | regulates | gene | 0.60 |
| UBIQUITIN | regulates | gene | 0.60 |
| PARK6 | regulates | gene | 0.60 |
| MAPK8 | contributes_to | gene | 0.60 |
| NFKBIA | contributes_to | gene | 0.60 |
| GFAP | regulates | gene | 0.60 |
| PINK1 | regulates | gene | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| CRISPR-Cas | participates_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| h-a11f71b5 | targets | hypothesis | 0.90 |
| HUWE1 | regulates | gene | 0.60 |
| TRIM25 | regulates | gene | 0.60 |
| PARKINSON'S DISEASE | regulates | gene | 0.60 |
| MICROGLIA | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning UBE3A in their description or question text
No additional research found