Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about VPS26: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
VPS26 is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, implicated in. Associated with Als, Ms. Connected to 17 entities in the SciDEX knowledge graph.
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| Gene Symbol | VPS26 |
| Chromosome | 10q21.3 |
| Function | encodes a critical component of the retromer complex, a key regulator of endosomal protein trafficking that has emerged as a central player in neurodegenerative disease pathogenesis. |
| Molecular Weight | 36.5 kDa |
| Amino Acids | 326 aa |
| Pathways | Autophagy |
| Ensembl ID | ENSG00000171208 |
| GeneCards | VPS26 |
| Human Protein Atlas | VPS26 |
| Associated Diseases | Als, Ms |
| Interactions | ABCA1, ABCA7, CD2AP, PICALM, ROS, VPS29 |
| KG Connections | 27 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
VPS26["VPS26"]
Als{"Als"}
VPS26 -->|"associated with"| Als
Ms{"Ms"}
VPS26 -->|"associated with"| Ms
AKT1["AKT1"]
VPS26 -->|"associated with"| AKT1
EGFR["EGFR"]
VPS26 -->|"associated with"| EGFR
MICRORNAS["MICRORNAS"]
VPS26 -->|"associated with"| MICRORNAS
AUTOPHAGY["AUTOPHAGY"]
VPS26 -->|"regulates"| AUTOPHAGY
SNAP29["SNAP29"]
VPS26 -->|"associated with"| SNAP29
Autophagy(["Autophagy"])
VPS26 -->|"regulates"| Autophagy
Akt(["Akt"])
VPS26 -->|"associated with"| Akt
Mtor(["Mtor"])
VPS26 -->|"associated with"| Mtor
Immune_Response(["Immune Response"])
VPS26 -->|"associated with"| Immune_Response
Endocytosis(["Endocytosis"])
VPS26 -->|"associated with"| Endocytosis
MTOR["MTOR"]
MTOR -->|"associated with"| VPS26
ERK["ERK"]
ERK -->|"regulates"| VPS26
RAC1["RAC1"]
RAC1 -->|"associated with"| VPS26
MIRNAS["MIRNAS"]
MIRNAS -->|"regulates"| VPS26
style VPS26 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Endocytosis | associated_with | pathway | 0.60 |
| Autophagy | regulates | pathway | 0.60 |
| Akt | associated_with | pathway | 0.60 |
| Mtor | associated_with | pathway | 0.60 |
| Immune Response | associated_with | pathway | 0.60 |
| MICRORNAS | associated_with | gene | 0.60 |
| AUTOPHAGY | regulates | gene | 0.60 |
| VPS35 | activates | gene | 0.60 |
| AKT1 | associated_with | gene | 0.60 |
| EGFR | associated_with | gene | 0.60 |
| SNAP29 | associated_with | gene | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| VPS35 | interacts_with | gene | 0.55 |
| VPS35 | binds_to | gene | 0.55 |
| VPS29 | binds_to | gene | 0.55 |
| VPS29 | interacts_with | gene | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning VPS26 in their description or question text
No additional research found