gene 1,704 words KG: VPS26
Contents

VPS26 Gene

🧬 Gene Info
Gene SymbolVPS26
Chromosome10q21.3
Functionencodes a critical component of the retromer complex, a key regulator of endosomal protein trafficking that has emerged as a central player in neurodegenerative disease pathogenesis.
Molecular Weight36.5 kDa
Amino Acids326 aa
PathwaysAutophagy
Ensembl IDENSG00000171208
GeneCardsVPS26
Human Protein AtlasVPS26
Associated DiseasesAls, Ms
InteractionsABCA1, ABCA7, CD2AP, PICALM, ROS, VPS29
KG Connections27 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Agent Input

Related Hypotheses (8)

Lysosomal Enzyme Trafficking Correction
Score: 0.71
Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution
Score: 0.68
Transcriptional Autophagy-Lysosome Coupling
Score: 0.92
APOE-Dependent Autophagy Restoration
Score: 0.88
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Autophagosome Maturation Checkpoint Control
Score: 0.71
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
VCP-Mediated Autophagy Enhancement
Score: 0.59

Related Analyses (3)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

Neurodegeneration
disease · KG edge: implicated_in
mTOR Signaling Dysregulation in Progressive Supranuclea
event · KG edge: associated_with
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: regulates
AKT1 Gene
gene · KG edge: associated_with
EGFR — Epidermal Growth Factor Receptor
gene · KG edge: associated_with

Knowledge Graph (12 edges)

MTOR associated_with VPS26
RAC1 associated_with VPS26
VPS26 associated_with AKT1
VPS26 associated_with EGFR
VPS26 associated_with SNAP29
VPS26 binds_to VPS29
VPS26 binds_to VPS35
VPS26 interacts_with VPS29
VPS26 interacts_with VPS35
ABCA1 activates VPS26

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