gene

TDP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TDP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections

0Hypotheses

0Analyses

33Outgoing

10Incoming

0Experiments

0Debates

Summary

TDP1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, activates, inhibits. Associated with ALS, Als, Cancer. Connected to 33 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TDP1
Full Name	Tyrosyl-DNA Phosphodiesterase 1
Chromosome	14q32.12
Function	The TDP1 gene encodes Tyrosyl-DNA Phosphodiesterase 1, involved in DNA repair and genomic stability
UniProt ID	Q9NZJ8
NCBI Gene ID	70099
Ensembl ID	ENSG00000124564
OMIM	605197
GeneCards	TDP1
Human Protein Atlas	TDP1
DNA repair	Critical for maintaining genomic integrity
Cell cycle regulation	Coordinates DNA repair with cell cycle progression
[Apoptosis](/entities/apoptosis)	Modulates apoptotic response to DNA damage
Neuronal survival	Essential for long-term neuronal survival
H493R	functional studies
Associated Diseases	neurodegeneration
Interactions	AND, App, CANCER, DNA, FEN1, HIF1A
KG Connections	43 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TDP1 — AlphaFold Q9NZJ8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TDP1 Gene

gene · 626 words

→

Pathway Diagram

graph TD
    TDP1["TDP1"]
    Cancer{"Cancer"}
    TDP1 -->|"activates"| Cancer
    Als{"Als"}
    TDP1 -->|"activates"| Als
    TDP1 -->|"therapeutic target"| Cancer
    TDP1 -->|"therapeutic target"| Als
    ALS{"ALS"}
    TDP1 -->|"activates"| ALS
    PNKP["PNKP"]
    TDP1 -->|"activates"| PNKP
    FEN1["FEN1"]
    TDP1 -->|"inhibits"| FEN1
    XPF["XPF"]
    TDP1 -->|"inhibits"| XPF
    XRCC1["XRCC1"]
    TDP1 -->|"activates"| XRCC1
    DNA["DNA"]
    TDP1 -->|"inhibits"| DNA
    SETX["SETX"]
    TDP1 -->|"activates"| SETX
    MAPK1["MAPK1"]
    TDP1 -->|"therapeutic target"| MAPK1
    XPG["XPG"]
    XPG -->|"inhibits"| TDP1
    SETX -->|"activates"| TDP1
    XPF -->|"inhibits"| TDP1
    PNKP -->|"activates"| TDP1
    NFKB1["NFKB1"]
    NFKB1 -->|"therapeutic target"| TDP1
    ERK["ERK"]
    ERK -->|"therapeutic target"| TDP1
    TRIM24["TRIM24"]
    TRIM24 -->|"therapeutic target"| TDP1
    FEN1 -->|"inhibits"| TDP1
    DNA -->|"inhibits"| TDP1
    AND["AND"]
    AND -->|"activates"| TDP1
    style TDP1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (33)

Target	Relation	Type	Str
TOP1	degrades	protein	0.90
Single-Strand Breaks	associated_with	process	0.85
Cancer	encodes	disease	0.65
Als	encodes	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
ALS	activates	disease	0.65
NEURODEGENERATIVE DISEASES	activates	gene	0.60
CANCER	activates	gene	0.60
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
Rb	inhibits	protein	0.60
HIF1A	interacts_with	gene	0.60
MAPK1	therapeutic_target	gene	0.60
Neuron	encodes	cell_type	0.60
Ras	activates	protein	0.60
App	activates	protein	0.60
AND	activates	gene	0.60
CTSD	therapeutic_target	gene	0.60
PNKP	activates	gene	0.60
FEN1	inhibits	gene	0.60
XPF	inhibits	gene	0.60
XRCC1	activates	gene	0.60
SETX	activates	gene	0.60
XPG	inhibits	gene	0.60
GENES	therapeutic_target	gene	0.60
Wnt	therapeutic_target	pathway	0.60
Nf-Κb	therapeutic_target	pathway	0.60
Neuron	activates	cell_type	0.60
Mapk	therapeutic_target	pathway	0.60
DNA	inhibits	gene	0.60
Neuron	expressed_in	cell_type	0.55

Incoming (10)

Source	Relation	Type	Str
XPF	inhibits	gene	0.60
PNKP	activates	gene	0.60
FEN1	inhibits	gene	0.60
XRCC1	activates	gene	0.60
DNA	inhibits	gene	0.60
XPG	inhibits	gene	0.60
SETX	activates	gene	0.60
NFKB1	therapeutic_target	gene	0.60
TRIM24	therapeutic_target	gene	0.60
ERK	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TDP1 in their description or question text

No additional research found