gene

XPF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about XPF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections

0Hypotheses

0Analyses

25Outgoing

18Incoming

0Experiments

0Debates

Summary

ERCC4 (XPF) - a critical DNA repair endonuclease involved in nucleotide excision repair, with links to xeroderma pigmentosum and neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	XPF
Aliases	ERCC4 (XPF)
Chromosome	16p13.12
Function	The complex recognizes and cleaves DNA at the 5' side of various DNA lesions, including
Primary Expression	all human tissues with particularly high levels in: - Testis: Highest expression (germ cell DNA repair) - Skin: High basal expression (UV expo
Molecular Weight	104 kDa
Amino Acids	966 aa
UniProt ID	Q92841
NCBI Gene ID	2072
OMIM	278760
GeneCards	XPF
Human Protein Atlas	XPF
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	AND, App, CANCER, DNA, FEN1, NEURODEGENERATIVE DISEASES
KG Connections	43 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: XPF — AlphaFold Q92841 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

XPF Gene

gene · 1246 words

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Pathway Diagram

graph TD
    XPF["XPF"]
    Cancer{"Cancer"}
    XPF -->|"activates"| Cancer
    Als{"Als"}
    XPF -->|"activates"| Als
    ALS{"ALS"}
    XPF -->|"activates"| ALS
    XRCC1["XRCC1"]
    XPF -->|"activates"| XRCC1
    PNKP["PNKP"]
    XPF -->|"activates"| PNKP
    XPG["XPG"]
    XPF -->|"inhibits"| XPG
    TDP1["TDP1"]
    XPF -->|"inhibits"| TDP1
    FEN1["FEN1"]
    XPF -->|"inhibits"| FEN1
    DNA["DNA"]
    XPF -->|"inhibits"| DNA
    SETX["SETX"]
    XPF -->|"activates"| SETX
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    XPF -->|"activates"| NEURODEGENERATIVE_DISEASES
    CANCER["CANCER"]
    XPF -->|"activates"| CANCER
    XPG -->|"inhibits"| XPF
    SETX -->|"activates"| XPF
    TDP1 -->|"inhibits"| XPF
    PNKP -->|"activates"| XPF
    FEN1 -->|"inhibits"| XPF
    DNA -->|"inhibits"| XPF
    AND["AND"]
    AND -->|"inhibits"| XPF
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"]
    NEURODEGENERATIVE_DISORDERS -->|"activates"| XPF
    NEURODEGENERATIVE_DISEASES -->|"activates"| XPF
    style XPF fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (25)

Target	Relation	Type	Str
Cancer	encodes	disease	0.65
Als	encodes	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
ALS	activates	disease	0.65
XPG	inhibits	gene	0.60
TDP1	inhibits	gene	0.60
FEN1	inhibits	gene	0.60
SETX	activates	gene	0.60
DNA	inhibits	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
CANCER	activates	gene	0.60
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
Ras	activates	protein	0.60
App	activates	protein	0.60
PNKP	activates	gene	0.60
Rb	inhibits	protein	0.60
XRCC1	activates	gene	0.60
PNKP	encodes	gene	0.60
XRCC1	encodes	gene	0.60
SETX	encodes	gene	0.60
AND	inhibits	gene	0.60
Neuron	activates	cell_type	0.60
Neuron	encodes	cell_type	0.60
Neuron	expressed_in	cell_type	0.55

Incoming (18)

Source	Relation	Type	Str
genes-xpf	linked_to	wiki_page	1.00
AND	inhibits	gene	0.60
DNA	inhibits	gene	0.60
RAD52	causes	gene	0.60
SETX	causes	gene	0.60
RAD52	targets	gene	0.60
SETX	targets	gene	0.60
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
XRCC1	activates	gene	0.60
CANCER	activates	gene	0.60
DNA	causes	gene	0.60
RNA	causes	gene	0.60
XPG	inhibits	gene	0.60
SETX	activates	gene	0.60
TDP1	inhibits	gene	0.60
PNKP	activates	gene	0.60
FEN1	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning XPF in their description or question text

No additional research found