concept

TOP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TOP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

13Connections

0Hypotheses

0Analyses

7Outgoing

6Incoming

0Experiments

0Debates

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💡 Concept Info

Name	TOP1
Key Genes/Proteins	PNKP, TDP1, XRCC1
Related Pathways	R-Loops

Pathway Diagram

graph TD
    TOP1[TOP1]
    TOP1 -->|causes| DNA_Double_Strand_Breaks[DNA Double-Strand Breaks]
    TOP1 -->|causes| Dna_Double_Strand_Breaks[Dna Double-Strand Breaks]
    TOP1 -->|interacts| R_Loops[R-Loops]
    TOP1 -->|modulates| Transcription[Transcription]
    TOP1 -->|data_in| benchmark_ot_ad_answer_key_TOP[benchmark_ot_ad_answer_key:TOP1]
    Irinotecan[Irinotecan] -->|targets| TOP1
    TDP1[TDP1] -->|degrades| TOP1
    XRCC1[XRCC1] -->|interacts| TOP1
    PNKP[PNKP] -->|involved_in| TOP1
    benchmark_ot_ad_answer_key_TOP -->|data_in| TOP1

Outgoing (7)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:TOP1	data_in	dataset_row	0.00
Dna Double-Strand Breaks	causes	process	0.95
DNA Double-Strand Breaks	causes	process	0.95
DNA Double-Strand Breaks	mediates	process	0.95
DNA Double-Strand Breaks	contributes_to	process	0.92
R-Loops	interacts_with	mechanism	0.85
Transcription	modulates	process	0.80

Incoming (6)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:TOP1	data_in	dataset_row	0.00
Irinotecan	targets	drug	0.95
TDP1	degrades	protein	0.90
PNKP	involved_in	protein	0.80
XRCC1	involved_in	protein	0.80
XRCC1	interacts_with	protein	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TOP1 in their description or question text

No additional research found