gene

XPG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about XPG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections

0Hypotheses

0Analyses

24Outgoing

9Incoming

0Experiments

0Debates

Summary

XPG is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, implicated in. Associated with ALS, Als, Cancer. Connected to 22 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	XPG
Full Name	Excision Repair Cross-Complementation Group 5 (XPG endonuclease)
Chromosome	13q33.2
Function	is a critical DNA repair gene that encodes a structure-specific endonuclease essential for nucleotide excision repair (NER).
Amino Acids	186 aa
UniProt ID	Q15772
NCBI Gene ID	6148
Ensembl ID	ENSG00000134899
OMIM	133530
GeneCards	XPG
Human Protein Atlas	XPG
Associated Diseases	neurodegeneration
Interactions	AND, App, CANCER, DNA, FEN1, NEURODEGENERATIVE DISEASES
KG Connections	33 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: XPG — AlphaFold Q15772 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ERCC5 (XPG) Gene — Excision Repair Cross-Complementation Group 5

gene · 1930 words

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Pathway Diagram

graph TD
    XPG["XPG"]
    Cancer{"Cancer"}
    XPG -->|"activates"| Cancer
    Als{"Als"}
    XPG -->|"activates"| Als
    ALS{"ALS"}
    XPG -->|"activates"| ALS
    SETX["SETX"]
    XPG -->|"activates"| SETX
    TDP1["TDP1"]
    XPG -->|"inhibits"| TDP1
    PNKP["PNKP"]
    XPG -->|"activates"| PNKP
    FEN1["FEN1"]
    XPG -->|"inhibits"| FEN1
    XPF["XPF"]
    XPG -->|"inhibits"| XPF
    XRCC1["XRCC1"]
    XPG -->|"activates"| XRCC1
    DNA["DNA"]
    XPG -->|"inhibits"| DNA
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    XPG -->|"activates"| NEURODEGENERATIVE_DISEASES
    CANCER["CANCER"]
    XPG -->|"activates"| CANCER
    XPF -->|"inhibits"| XPG
    PNKP -->|"activates"| XPG
    FEN1 -->|"inhibits"| XPG
    SETX -->|"activates"| XPG
    TDP1 -->|"inhibits"| XPG
    DNA -->|"inhibits"| XPG
    AND["AND"]
    AND -->|"inhibits"| XPG
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"]
    NEURODEGENERATIVE_DISORDERS -->|"activates"| XPG
    style XPG fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (24)

Target	Relation	Type	Str
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Cancer	encodes	disease	0.65
Als	encodes	disease	0.65
ALS	activates	disease	0.65
App	activates	protein	0.60
SETX	activates	gene	0.60
TDP1	inhibits	gene	0.60
PNKP	activates	gene	0.60
FEN1	inhibits	gene	0.60
XPF	inhibits	gene	0.60
XRCC1	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
CANCER	activates	gene	0.60
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
Ras	activates	protein	0.60
Rb	inhibits	protein	0.60
DNA	inhibits	gene	0.60
Neuron	activates	cell_type	0.60
AND	inhibits	gene	0.60
Neuron	encodes	cell_type	0.60
XRCC1	encodes	gene	0.60
SETX	encodes	gene	0.60
Neuron	expressed_in	cell_type	0.55

Incoming (9)

Source	Relation	Type	Str
XRCC1	activates	gene	0.60
PNKP	encodes	gene	0.60
FEN1	inhibits	gene	0.60
SETX	activates	gene	0.60
TDP1	inhibits	gene	0.60
DNA	inhibits	gene	0.60
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
XPF	inhibits	gene	0.60
PNKP	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning XPG in their description or question text

No additional research found