concept

SPHINGOLIPID METABOLISM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SPHINGOLIPID METABOLISM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

87Connections

1Hypotheses

2Analyses

10Outgoing

50Incoming

4Experiments

3Debates

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💡 Concept Info

Name	SPHINGOLIPID METABOLISM
Key Genes/Proteins	AMYLOID, APP, IL-10
Related Diseases	ALZHEIMER'S DISEASE, DEMENTIA, PARKINSON'S DISEASE, PULMONARY FIBROSIS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Sphingolipid Metabolism in Neurodegeneration

mechanism · 1980 words

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Pathway Diagram

graph TD
    SPHINGOLIPID_METABOLISM["SPHINGOLIPID METABOLISM"]
    SPHINGOLIPID_METABOLISM -->|"contributes to"| Inflammation["Inflammation"]
    SPHINGOLIPID_METABOLISM -->|"involved_in"| Alzheimer_s_Disease["Alzheimer's Disease"]
    SPHINGOLIPID_METABOLISM -->|"contributes to"| Endoplasmic_Reticulum_Stress["Endoplasmic Reticulum Stress"]
    SPHINGOLIPID_METABOLISM -->|"involved_in"| Parkinson_s_Disease["Parkinson's Disease"]
    SPHINGOLIPID_METABOLISM -->|"inhibits"| STEM_CELLS["STEM CELLS"]
    EMP1["EMP1"] -->|"inhibits"| SPHINGOLIPID_METABOLISM
    IL_10["IL-10"] -->|"inhibits"| SPHINGOLIPID_METABOLISM
    IL10["IL10"] -->|"inhibits"| SPHINGOLIPID_METABOLISM
    GLUCOCEREBROSIDASE["GLUCOCEREBROSIDASE"] -->|"catalyzes"| SPHINGOLIPID_METABOLISM
    ASMASE["ASMASE"] -->|"involved_in"| SPHINGOLIPID_METABOLISM

Outgoing (10)

Target	Relation	Type	Str
Inflammation	contributes_to	process	0.90
Alzheimer's Disease	involved_in	disease	0.90
Parkinson's Disease	involved_in	disease	0.85
Hematopoietic Stem Cells	regulates	cell_type	0.85
ceramides	involved_in	compound	0.85
Inflammation	promotes	process	0.85
Endoplasmic Reticulum Stress	contributes_to	process	0.85
Endoplasmic Reticulum Stress	causes	process	0.85
Alzheimer's disease	associated_with	disease	0.70
STEM CELLS	inhibits	cell_type	0.35

Incoming (77)

Source	Relation	Type	Str
EMP1	inhibits	protein	0.95
IL10	inhibits	gene	0.95
IL-10	inhibits	protein	0.95
ASAH1	involved_in	enzyme	0.90
NSMASE	involved_in	enzyme	0.90
ASMASE	involved_in	enzyme	0.90
Alzheimer's Disease	associated_with	disease	0.90
IL10	inhibits	entity	0.90
EMP1	inhibits	entity	0.90
IL-10	modulates	protein	0.90
IL10	regulates	entity	0.85
Huanglian Jiedu Decoction	modulates	drug	0.85
oligodendrocytes	active_in	cell_type	0.85
Glucocerebrosidase	regulates	enzyme	0.85
EMP1	associated_with	gene	0.80
IL-10	associated_with	entity	0.80
EMP1	associated_with	gene	0.80
Alzheimer's disease	involves	disease	0.75
APOE	participates_in	gene	0.75
APP	participates_in	gene	0.75
DAM microglia	active_in	cell_type	0.75
neurons	active_in	cell_type	0.75
APOE4	participates_in	gene	0.75
SMPD1	regulates	protein	0.70
Ginsenoside Rg1	regulates	drug	0.70
TNF	regulates	protein	0.70
PS1	participates_in	gene	0.65
neurodegeneration	involves	disease	0.65
BACE1	participates_in	gene	0.65
astrocytes	active_in	cell_type	0.65
SPTLC1	participates_in	gene	0.65
APOE3	participates_in	gene	0.65
SPTLC1	regulates	gene	0.60
SMPD1	involved_in	gene	0.60
CERS2	participates_in	gene	0.55
CERS6	participates_in	gene	0.55
CERS1	participates_in	gene	0.55
microglia	active_in	cell_type	0.55
JNK	participates_in	gene	0.55
B4GALNT1	participates_in	gene	0.55
LDL	participates_in	gene	0.55
DNA	participates_in	gene	0.55
NMDA	participates_in	gene	0.55
ALS	participates_in	gene	0.55
Parkinson's disease	involves	disease	0.55
SMS2	participates_in	gene	0.55
BAK	participates_in	gene	0.55
TREM2	participates_in	gene	0.55
DAP12	participates_in	gene	0.55
SMPD1	participates_in	gene	0.55

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Sphingolipid Metabolism Reprogramming	0.663	neurodegeneration	4R-tau strain-specific spreading pattern

Mentioning Analyses (2)

Scientific analyses that reference this entity

Which specific metabolic pathways in APOE4+ microglia are most therapeutically t

neurodegeneration | 2026-04-08 | 0 hypotheses

4R-tau strain-specific spreading patterns in PSP vs CBD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.732

Experiments (4)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
CERS2 genetic deletion rescues IL-10 deficiency inflammation	validation	inflammatory bowel disease	0.850	0.00	IL-10/CERS2 double knockout mi	proposed	N/A
Lipid Droplet-Lysosome Axis Therapeutic Testing in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Validation: Membrane-Nucleation in iPSC Neurons	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,730,000
Oligodendrocyte-Myelin Dysfunction Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,100,000

Related Papers (17)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
EMP1 safeguards hematopoietic stem cells by suppressing sphingolipid metabolism [PMID:40624017]	Li L, Lei Y, Li Y, Xie Y, Hui P, Zang X,	Nat Commun	2025	1
IL-10 constrains sphingolipid metabolism to limit inflammation. [PMID:38383790]	York AG, Skadow MH, Oh J, Qu R, Zhou QD,	Nature	2024	1
PAQR4 regulates adipocyte function and systemic metabolic health by mediating ce [PMID:38961186]	Zhu Q, Chen S, Funcke JB, Straub LG, Lin	Nat Metab	2024	1
Sirtuin 1 mediated ceramide metabolism regulates intestinal mechanical barrier f [PMID:41856194]	Ma X, Liu Q, Mai K, Zhang Y	Int J Biol Macromol	2026	0
Metabolic abnormalities and reprogramming in cats with naturally occurring hyper [PMID:39499136]	["Li Q", "Homilius M", "Achilles E", "Ma	ESC heart failure	2025	0
Reduced circulating sphingolipids and CERS2 activity are linked to T2D risk and [PMID:39792658]	Khan SR, Ye WW, Van JAD, Singh I, Rabiee	Science advances	2025	0
Very long-chain fatty acids drive 1-deoxySphingolipid toxicity. [PMID:41298489]	["Majcher A", "Karsai G", "Yusifov E", "	Nature communications	2025	0
A multi-omics approach identifies the key role of disorders of sphingolipid meta [PMID:39638825]	["Qu Y", "Ma D", "Wu T", "Wang H", "Tian	Scientific reports	2024	0
Disruption of adipocyte HIF-1α improves atherosclerosis through the inhibition o [PMID:35847503]	Wang P, Zeng G, Yan Y, Zhang SY, Dong Y,	Acta pharmaceutica Sinica. B	2022	0
Fumonisin B [PMID:35777715]	["Li M", "Liu S", "Tan L", "Luo Y", "Gao	Food and chemical toxicology :	2022	0
Omega-3 polyunsaturated fatty acids reverse the impact of western diets on regul [PMID:35985403]	["Camacho-Mu\u00f1oz D", "Niven J", "Kuc	Biochemical pharmacology	2022	0
Metabolic Reprogramming-A New Era How to Prevent and Treat Graft Versus Host Dis [PMID:33343357]	["Kumari R", "Palaniyandi S", "Hildebran	Frontiers in pharmacology	2020	0
Evolution to the rescue: using comparative genomics to understand long non-codin [PMID:27573374]	["Ulitsky I"]	Nature reviews. Genetics	2016	0
New insights into the organ-specific adverse effects of fumonisin B1: comparison [PMID:25155190]	["Loiseau N", "Polizzi A", "Dupuy A", "T	Archives of toxicology	2015	0
Hereditary colorectal cancer syndromes: American Society of Clinical Oncology Cl [PMID:25452455]	["Stoffel E", "Mangu P", "Gruber S", "Ha	Journal of clinical oncology :	2015	0
Ceramide synthase 4 deficiency in mice causes lipid alterations in sebum and res [PMID:24738593]	["Ebel P", "Imgrund S", "Vom Dorp K", "H	The Biochemical journal	2014	0
Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determine [PMID:23209295]	["Zhu Y", "Massen S", "Terenzio M", "Lan	The Journal of biological chem	2013	0

Debates (3)

Multi-agent debates referencing this entity

PSP and CBD both involve 4R-tau but produce distinct neuropathological patterns

closed · Rounds: 4 · Score: 0.69 · 2026-04-12

PSP and CBD both involve 4R-tau but produce distinct neuropathological patterns

closed · Rounds: 7 · Score: 0.91 · 2026-04-10

While APOE4 disrupts microglial metabolism broadly, the debate didn't identify w

closed · Rounds: 4 · Score: 0.92 · 2026-04-09

Related Research

Hypotheses and analyses mentioning SPHINGOLIPID METABOLISM in their description or question text

No additional research found