gene

asah1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about asah1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

85Connections

0Hypotheses

0Analyses

50Outgoing

14Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	ASAH1
Full Name	N-Acylsphingosine Amidohydrolase 1
Chromosome	8p22
Protein Type	Enzyme
Function	is a lysosomal enzyme that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids.
Molecular Weight	~44 kDa (precursor), ~13+20 kDa (processed)
Amino Acids	395 aa
Exons	16
Pathways	Sphingolipid
UniProt ID	[Q13510](https://www.uniprot.org/uniprot/Q13510)
Ensembl ID	ENSG00000104522
OMIM	613468
GeneCards	ASAH1
Human Protein Atlas	ASAH1
Associated Diseases	Aging, Als, Ms, Parkinson, Parkinson's disease
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, Aβ, CERS2
KG Connections	75 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ASAH1 — N-Acylsphingosine Amidohydrolase 1

gene · 1077 words

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Pathway Diagram

graph TD
    ASAH1["ASAH1"]
    ASAH1 -->|"involved_in"| Sphingolipid_Metabolism["Sphingolipid Metabolism"]
    ASAH1 -->|"contributes to"| Parkinson_s_disease["Parkinson's disease"]
    ASAH1 -->|"activates"| Alzheimer["Alzheimer"]
    ASAH1 -->|"activates"| Als["Als"]
    ASAH1 -->|"expressed in"| Ischemia["Ischemia"]
    ASAH1 -->|"expressed in"| Stroke["Stroke"]
    ASAH1 -->|"activates"| ALS["ALS"]
    SGMS2["SGMS2"] -->|"activates"| ASAH1
    AMYLOID["AMYLOID"] -->|"activates"| ASAH1
    CERS6["CERS6"] -->|"activates"| ASAH1
    ALZHEIMER["ALZHEIMER"] -->|"activates"| ASAH1
    STROKE["STROKE"] -->|"expressed in"| ASAH1
    APOPTOSIS["APOPTOSIS"] -->|"expressed in"| ASAH1
    GENES["GENES"] -->|"activates"| ASAH1

Outgoing (71)

Target	Relation	Type	Str
Sphingolipid Metabolism	involved_in	process	0.90
Parkinson's disease	contributes_to	disease	0.80
Aging	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
Als	activates	disease	0.65
ALS	activates	disease	0.65
Ischemia	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
ALS	associated_with	disease	0.65
ALS	expressed_in	disease	0.65
Stroke	expressed_in	disease	0.65
Parkinson	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
SLC17A5	interacts_with	gene	0.60
SMPD1	associated_with	gene	0.60
GBA1	implicated_in	gene	0.60
SMPD1	implicated_in	gene	0.60
GBA1	expressed_in	gene	0.60
AND	associated_with	gene	0.60
GENES	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
LYSOSOMAL STORAGE DISORDER GENE VARIANTS	associated_with	gene	0.60
Lipid Metabolism	activates	pathway	0.60
Lipid Metabolism	contributes_to	pathway	0.60
Apoptosis	expressed_in	pathway	0.60
Neuron	expressed_in	cell_type	0.60
PARKINSON	associated_with	gene	0.60
ALZHEIMER	activates	gene	0.60
AND	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
AMYLOID	activates	gene	0.60
Amyloid	activates	pathway	0.60
Sphingolipid	activates	pathway	0.60
AND	contributes_to	gene	0.60
STROKE	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
SMPD1	interacts_with	gene	0.60
CTSD	associated_with	gene	0.60
GBA	associated_with	gene	0.60
CERS2	activates	gene	0.60
SGMS1	activates	gene	0.60
SGMS1	contributes_to	gene	0.60
CERS6	activates	gene	0.60
SGMS2	activates	gene	0.60
SGMS2	contributes_to	gene	0.60
SLC17A5	associated_with	gene	0.60
SGMS1	regulates	gene	0.60
SGMS2	regulates	gene	0.60
CTSD	interacts_with	gene	0.60

Incoming (14)

Source	Relation	Type	Str
GENES	associated_with	gene	0.60
SGMS2	activates	gene	0.60
CERS6	activates	gene	0.60
SGMS2	contributes_to	gene	0.60
SMPD1	associated_with	gene	0.60
SLC17A5	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
AMYLOID	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
STROKE	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
GENES	activates	gene	0.60
GENES	expressed_in	gene	0.60
SGMS2	associated_with	gene	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity