gene

CLTC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CLTC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12Connections

0Hypotheses

0Analyses

9Outgoing

3Incoming

0Experiments

0Debates

Summary

Page for CLTC Gene

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🧬 Gene Info

Gene Symbol	CLTC
Full Name	Clathrin Heavy Chain 1
Chromosome	17q23.2
Function	Clathrin-mediated endocytosis (CME) is the primary pathway for synaptic vesicle recycling in neurons and for receptor-mediated endocytosis in all cell types.
Molecular Weight	192 kDa
Pathways	Inflammasome
UniProt ID	[Q00610](https://www.uniprot.org/uniprot/Q00610)
Ensembl ID	ENSG00000130224
OMIM	118955
GeneCards	CLTC
Human Protein Atlas	CLTC
Core Components	CLTA (clathrin light chain), DNM1/DNM2 (dynamins), Amphiphysin (RBS)
Adaptor Proteins	AP2 complex, AP180/CALM, epsin, dynamin
Neuronal Function	Synaptic vesicle endocytosis, receptor trafficking, neurotrophin signaling
Associated Diseases	neurodegeneration
Interactions	Insulin, NLRP3
KG Connections	12 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CLTC Gene

gene · 590 words

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Pathway Diagram

flowchart TD
    CLTC(["CLTC"])
    Fibrosis["Fibrosis"]
    Inflammasome["Inflammasome"]
    Macrophage["Macrophage"]
    Hepatocyte["Hepatocyte"]
    Insulin(["Insulin"])
    NLRP3(["NLRP3"])
    neurodegeneration["neurodegeneration"]

    CLTC -->|"activates"| Fibrosis
    CLTC -->|"activates"| Inflammasome
    CLTC -.->|"inhibits"| Macrophage
    CLTC -->|"activates"| Hepatocyte
    CLTC -->|"activates"| Insulin
    NLRP3 -->|"activates"| CLTC
    CLTC -->|"implicated in"| neurodegeneration

    style CLTC fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (9)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CLTC	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Fibrosis	activates	disease	0.65
Insulin	activates	protein	0.60
Hepatocyte	activates	cell_type	0.60
Inflammasome	activates	pathway	0.60
Macrophage	inhibits	cell_type	0.60
SORCS2	regulates	gene	0.60
SORL1	regulates	gene	0.60

Incoming (3)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CLTC	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
NLRP3	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CLTC in their description or question text

No additional research found