Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SLE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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SLE["SLE"]
VEGFA["VEGFA"] -->|"implicated in"| SLE
EEF1A1["EEF1A1"] -->|"implicated in"| SLE
APOB["APOB"] -->|"implicated in"| SLE
MET["MET"] -->|"implicated in"| SLE
MCL1["MCL1"] -->|"implicated in"| SLE
SF3B1["SF3B1"] -->|"implicated in"| SLE
IDH1["IDH1"] -->|"implicated in"| SLE
SMARCA4["SMARCA4"] -->|"implicated in"| SLE| Target | Relation | Type | Str |
|---|---|---|---|
| pSS | associated_with | disease | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| RBP | associated_with | protein | 0.56 |
| VEGFA | implicated_in | gene | 0.50 |
| EEF1A1 | implicated_in | gene | 0.50 |
| APOB | implicated_in | gene | 0.50 |
| MET | implicated_in | gene | 0.50 |
| MCL1 | implicated_in | gene | 0.50 |
| SF3B1 | implicated_in | gene | 0.50 |
| IDH1 | implicated_in | gene | 0.50 |
| SMARCA4 | implicated_in | gene | 0.50 |
| DNA | implicated_in | gene | 0.50 |
| LZTR1 | implicated_in | gene | 0.50 |
| MDM4 | implicated_in | gene | 0.50 |
| TERT | implicated_in | gene | 0.50 |
| CD40 | implicated_in | gene | 0.50 |
| AQP4 | implicated_in | gene | 0.50 |
| TCR | implicated_in | gene | 0.50 |
| TNF | associated_with | gene | 0.50 |
| HSPA1A | implicated_in | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Sleep-Dependent Glymphatic Clearance Expands the Therapeutic | 0.780 | neurodegeneration | What is the therapeutic window between t |
| Night-phase orexin receptor antagonism rescues AD by restori | 0.758 | neurodegeneration | Orexin-A manipulation in AD cognition an |
| Sleep Spindle-Synaptic Plasticity Enhancement | 0.721 | neurodegeneration | Sleep disruption as cause and consequenc |
| Biorhythmic Interference via Controlled Sleep Oscillations | 0.661 | neurodegeneration | Microglia-astrocyte crosstalk amplificat |
| Treat Glymphatic Failure by Coupling AQP4-Targeted Therapy t | 0.630 | neurodegeneration | How can AQP4 be effectively targeted the |
| A lower trazodone dose of 50-100 mg nightly may be sufficien | 0.580 | neurodegeneration | - |
| Restorative Sleep Induction as the Threshold Mechanism: Dose | 0.545 | - | What is the minimum effective dose of tr |
| Complement Regulator CD55/CD46 Expression Modulates Microgli | 0.000 | synaptic biology | What determines the selectivity of compl |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Phenobarbital treatment efficacy study | clinical | intractable epilepsy | 0.900 | 0.00 | human patient and Gabra1+/-/Ga | proposed | N/A |
| Gabra1+/-/Gabrg2+/- mouse model characterization | validation | epilepsy with optic atrophy | 0.900 | 0.00 | Gabra1+/-/Gabrg2+/- mice | proposed | N/A |
| Optic nerve myelination analysis | exploratory | optic atrophy | 0.880 | 0.00 | Gabra1+/-/Gabrg2+/- mice | proposed | N/A |
| GABAA receptor subunit expression analysis | exploratory | epilepsy | 0.850 | 0.00 | Gabra1+/-/Gabrg2+/- mice | proposed | N/A |
| Brain Connectivity-Targeted tACS Trial in Early AD | clinical | Alzheimer's Disease | 0.509 | 0.50 | human postmortem brain tissue | proposed | $520,000 |
| s:** - Test whether HCN1 knockout specifically in EC layer II accelera | falsification | Alzheimer's Disease | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| tACS Connectivity Trial in Early Alzheimer's | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Brain Connectivity-Targeted tACS Trial in Early AD | clinical | Alzheimer's Disease | 0.400 | 0.50 | mouse | proposed | $730,000 |
| DLB Cognitive Fluctuation Mechanism Experiment | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Migraine Cortical Hyperexcitability and Alzheimer's Disease Risk: Long | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Neural Oscillation Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Non-Motor Symptom Progression in Parkinson's Disease — Mechanisms and | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Sleep and Circadian Dysfunction as Driver of Neurodegeneration | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Sleep Disruption and Alzheimer's Disease — mechanism and intervention | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Proposed experiment from debate on Astrocytes adopt A1 (neurotoxic) an | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Non-Dopaminergic Neurotransmitter Degeneration in PD - Experiment Desi | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| A brain-to-gut signal controls intestinal fat absorption. [PMID:39261733] | Lyu Q, Xue W, Liu R, Ma Q, Kasaragod VB, | Nature | 2024 | 1 |
| Epilepsy plus blindness in microdeletion of GABRA1 and GABRG2 in mouse and human [PMID:37703949] | Zhang Q, Forster-Gibson C, Bercovici E, | Exp Neurol | 2023 | 1 |
| Pharmacogenetics of anxiety and depression in Alzheimer's disease. [PMID:36628952] | Cacabelos R, Carril JC, Corzo L, Pego R, | Pharmacogenomics | 2023 | 1 |
| Genetic factors in precocious puberty. [PMID:34665958] | Shim YS, Lee HS, Hwang JS | Clin Exp Pediatr | 2022 | 1 |
| Sleep drives metabolite clearance from the adult brain. [PMID:24136970] | Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th | Science | 2013 | 1 |
| Effects of caffeine on sleep and cognition. [PMID:21531247] | Snel J, Lorist MM | Prog Brain Res | 2011 | 1 |
| Functional dissection of Timekeeper (Tik) implicates opposite roles for CK2 and [PMID:19536808] | Kunttas-Tatli E, Bose A, Kahali B, Bisho | Genesis | 2009 | 1 |
| CI-994 is a dual modulator of class I HDACs and Wnt/β-catenin signaling for the [PMID:41654970] | Lu W, Kawatani K, Ren Y | Alzheimers Res Ther | 2026 | 0 |
| Molecular brake on firing pattern transitions in MHbChAT neurons to mediate nico [PMID:41903536] | Zheng ZW, Min PX, Luo YL, Mao XF, Zhang | Neuron | 2026 | 0 |
| Estradiol modulates neuronal network hyperexcitability in select NDD risk genes. [PMID:41757108] | Pruitt A, Yang L, Lee S, Balafkan N, Sea | bioRxiv : the preprint server | 2026 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Prenatal alcohol exposure dysregulates the expression of clock genes and alters [PMID:41086861] | Reina-Campos M, Gallego-Landin I, Medran | Open biology | 2025 | 0 |
| Sleep-improving effect and the potential mechanism of Morus alba L. on mice. [PMID:39255910] | Kong X, Zhou X, Li R, Kang Q, Hao L, Zhu | Fitoterapia | 2024 | 0 |
| Vitamin D supplementation and COVID-19 risk: a population-based, cohort study. [PMID:34273098] | ["Oristrell J", "Oliva J", "Casado E", " | Journal of endocrinological in | 2022 | 0 |
| Intracellular calcium homeostasis and its dysregulation underlying epileptic sei [PMID:36403388] | Zhou X, Chen Z, Xiao L, Zhong Y, Liu Y, | Seizure | 2022 | 0 |
| To beat Omicron, Delta and bird flu, Europe must pull together [PMID:34893768] | Desvars-Larrive Amélie | Nature | 2021 | 0 |
| Facilitating successful online meetings in healthcare. [PMID:33789331] | Dennis Sherrod; Cecil Holland | Nursing management | 2021 | 0 |
| Homeostatic plasticity and burst activity are mediated by hyperpolarization-acti [PMID:33547341] | Rátkai A, Tárnok K, Aouad HE, Micska B, | Scientific reports | 2021 | 0 |
| Machine learning reveals bilateral distribution of somatic L1 insertions in huma [PMID:33432196] | ["Zhu X", "Zhou B", "Pattni R", "Gleason | Nature neuroscience | 2021 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SLE in their description or question text
Score: 0.545 · unknown disease · 2026-04-26
At doses of 50-100 mg, trazodone increases slow-wave sleep continuity and REM duration, indirectly enhancing glymphatic
Score: 0.000 · synaptic biology · 2026-04-27
The circadian-regulated expression of complement regulators CD55 and CD46 on synaptic membranes establishes a temporal g