concept

PI3K/AKT/MTOR PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PI3K/AKT/MTOR PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

91Connections

0Hypotheses

1Analyses

50Outgoing

32Incoming

0Experiments

5Debates

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💡 Concept Info

Name	PI3K/AKT/MTOR PATHWAY

Pathway Diagram

graph TD
    PI3K_AKT_MTOR_PATHWAY["PI3K/AKT/MTOR PATHWAY"]
    PI3K_AKT_MTOR_PATHWAY -->|"involved_in"| Cancer["Cancer"]
    PI3K_AKT_MTOR_PATHWAY -->|"contributes to"| Hormone_Receptor_Positive_Adva["Hormone Receptor-Positive Advanced Breast Cancer"]
    PI3K_AKT_MTOR_PATHWAY -->|"involved_in"| Breast_Cancer["Breast Cancer"]
    PI3K_AKT_MTOR_PATHWAY -->|"promotes"| Tumor_Growth["Tumor Growth"]
    PI3K_AKT_MTOR_PATHWAY -->|"mediates"| Endocrine_Therapy_Resistance["Endocrine Therapy Resistance"]
    PI3K_AKT_MTOR_PATHWAY -->|"mediates"| Cdk4_6_Inhibitor_Resistance["Cdk4/6 Inhibitor Resistance"]
    PI3K_AKT_MTOR_PATHWAY -->|"promotes"| cell_survival["cell survival"]
    PI3K_AKT_MTOR_PATHWAY -->|"promotes"| dystrophic_neurites["dystrophic neurites"]
    Piperine["Piperine"] -->|"activates"| PI3K_AKT_MTOR_PATHWAY
    PIK3CA["PIK3CA"] -->|"involved_in"| PI3K_AKT_MTOR_PATHWAY
    CHRYSOTOXINE["CHRYSOTOXINE"] -->|"inhibits"| PI3K_AKT_MTOR_PATHWAY
    Capivasertib["Capivasertib"] -->|"inhibits"| PI3K_AKT_MTOR_PATHWAY
    Alpelisib["Alpelisib"] -->|"inhibits"| PI3K_AKT_MTOR_PATHWAY
    MARCKS["MARCKS"] -->|"activates"| PI3K_AKT_MTOR_PATHWAY
    insulin_resistance["insulin resistance"] -->|"inhibits"| PI3K_AKT_MTOR_PATHWAY
    STX11["STX11"] -->|"inhibits"| PI3K_AKT_MTOR_PATHWAY

Outgoing (59)

Target	Relation	Type	Str
Insulin Resistance	regulates	phenotype	0.95
insulin resistance	regulates	process	0.95
Cancer	involved_in	disease	0.95
Breast Cancer	involved_in	disease	0.95
Hormone Receptor-Positive Advanced Breast Cancer	contributes_to	disease	0.95
Tumor Growth	promotes	process	0.95
Breast Tumorigenesis	involved_in	process	0.95
Colorectal Cancer Progression	involved_in	process	0.95
Colorectal Cancer Metastasis	promotes	process	0.95
Colorectal Cancer Initiation	involved_in	process	0.95
Cdk4/6 Inhibitor Resistance	mediates	mechanism	0.93
Endocrine Therapy Resistance	mediates	mechanism	0.93
cell survival	promotes	process	0.92
dystrophic neurites	promotes	phenotype	0.92
cytoskeleton dynamics	regulates	process	0.90
lipid transport	regulates	process	0.90
axonal pathology	therapeutic_target	phenotype	0.90
Breast cancer	implicated_in	disease	0.90
Colorectal cancer	implicated_in	disease	0.90
Triple-negative breast cancer	implicated_in	disease	0.90
Autophagy	mediates	process	0.90
Transcriptional Targets	regulates	process	0.90
Gene Transcription	regulates	process	0.90
protein turnover	regulates	process	0.90
Pancreatic Ductal Adenocarcinoma	involved_in	disease	0.90
Cancer Progression	regulates	disease	0.90
Autophagy	mediates	process	0.90
macrophage activation	regulates	phenotype	0.90
Tumor Growth	involved_in	process	0.90
Endocrine Resistance	mediates	mechanism	0.90
Poor Prognosis	associated_with	phenotype	0.90
insulin resistance	causes	phenotype	0.90
Drug Resistance	mediates	phenotype	0.90
Tumor Invasion	involved_in	process	0.85
Cytoskeleton Dynamics	regulates	process	0.85
Lipid Transport	regulates	process	0.85
Bladder Cancer	drives	disease	0.85
Hormone-Receptor-Positive Breast Cancer	contributes_to	disease	0.85
Apoptosis	regulates	process	0.85
Autophagy	regulates	process	0.85
Protein Turnover	regulates	process	0.85
Sjogren's Syndrome	involved_in	disease	0.85
Cancer Hallmarks	regulates	process	0.85
Cellular Growth	modulates	process	0.85
Cell Proliferation	regulates	process	0.85
Idiopathic Pulmonary Fibrosis	involved_in	disease	0.85
Tumor Metastasis	associated_with	process	0.83
Cell Death	modulates	process	0.80
Salivary Gland Damage	involved_in	phenotype	0.80
insulin resistance	protects_against	phenotype	0.80

Incoming (32)

Source	Relation	Type	Str
PIK3CA	associated_with	gene	0.95
Glioblastoma Multiforme	associated_with	disease	0.95
Piperine	activates	compound	0.95
PI3K Pathway Inhibitors	inhibits	drug	0.95
Apigenin	inhibits	compound	0.95
Polyphenols	targets	compound	0.95
Alpelisib	inhibits	drug	0.92
Capivasertib	inhibits	drug	0.92
PTEN	inhibits	protein	0.90
Mtor Inhibitors	inhibits	drug	0.90
STX11	inhibits	gene	0.90
insulin resistance	inhibits	phenotype	0.90
SPP1	activates	protein	0.90
Berberine	inhibits	compound	0.90
Fibroblast Autophagy	inhibits	process	0.90
MARCKS	activates	protein	0.90
SYK	activates	protein	0.90
PTEN	regulates	gene	0.90
Pi3K Inhibitors	inhibits	drug	0.90
Akt Inhibitors	inhibits	drug	0.90
PTEN	inhibits	gene	0.90
Piperine	activates	compound	0.90
Sijunzi Decoction	targets	drug	0.90
41594924	promotes pro-survival autophagy by inhibiting	paper	0.90
MTOR	involved_in	gene	0.88
AKT1	involved_in	gene	0.88
IRGM1	activates	protein	0.85
KRAS	activates	gene	0.85
NOBILETIN	inhibits	compound	0.80
RAF/MEK/ERK Pathway	interacts_with	pathway	0.75
41594924	inhibits	paper	0.60
Gomisin N	activates	compound	0.60