gene

NMNAT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NMNAT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

24Connections

0Hypotheses

0Analyses

17Outgoing

7Incoming

0Experiments

0Debates

Summary

Page for NMNAT1 Gene

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🧬 Gene Info

Gene Symbol	NMNAT1
Full Name	Nicotinamide Mononucleotide Adenylyltransferase 1
Chromosome	1p36.22
Protein Type	Enzyme
Function	encodes a crucial enzyme in NAD+ biosynthesis that catalyzes the final step in the NAD+ salvage pathway: the conversion of nicotinamide mononucleotide (NMN) to nicotinamide adenine dinucleotide (NA...
Primary Expression	tissues with high metabolic demand
Subcellular Localization	s and tissue expression patterns. While NMNAT1 is primarily studied in the context of Leber congenital amaurosis (LCA)
Molecular Weight	32 kDa
Amino Acids	279 aa
Exons	13
UniProt ID	[Q9PVN7](https://www.uniprot.org/uniprot/Q9PVN7)
Ensembl ID	ENSG00000160714
OMIM	608709
GeneCards	NMNAT1
Human Protein Atlas	NMNAT1
Associated Diseases	neurodegeneration
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AND, AXON, Caspase, CASPASE-3
KG Connections	24 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NMNAT1 Gene

gene · 2466 words

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NMNAT1 Protein

protein · 1260 words

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Pathway Diagram

graph TD
    NMNAT1["NMNAT1"]
    Alzheimer{"Alzheimer"}
    NMNAT1 -.->|"inhibits"| Alzheimer
    Oxidative_Stress["Oxidative Stress"]
    NMNAT1 -.->|"inhibits"| Oxidative_Stress
    Dopaminergic["Dopaminergic"]
    NMNAT1 -.->|"inhibits"| Dopaminergic
    Neuron["Neuron"]
    NMNAT1 -.->|"inhibits"| Neuron
    NEURON(["NEURON"])
    NMNAT1 -.->|"inhibits"| NEURON
    ALZHEIMER_S_DISEASE(["ALZHEIMER'S DISEASE"])
    NMNAT1 -.->|"inhibits"| ALZHEIMER_S_DISEASE
    NAD(["NAD"])
    NAD -.->|"inhibits"| NMNAT1
    ALZHEIMER(["ALZHEIMER"])
    ALZHEIMER -.->|"inhibits"| NMNAT1
    AXON(["AXON"])
    AXON -.->|"inhibits"| NMNAT1
    style NMNAT1 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (17)

Target	Relation	Type	Str
Alzheimer	inhibits	disease	0.65
Oxidative Stress	inhibits	pathway	0.60
Dopaminergic	inhibits	cell_type	0.60
Neuron	inhibits	cell_type	0.60
Rb	inhibits	protein	0.60
NEURON	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
NAD	inhibits	gene	0.60
Caspase	inhibits	protein	0.60
Substantia Nigra	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55
ALZHEIMER	inhibits	gene	0.50
oxidative stress	inhibits	phenotype	0.50
CASPASE-3	inhibits	protein	0.50
disease	inhibits	disease	0.50
ALZHEIMER'S	inhibits	concept	0.50
Alzheimer'S Disease	inhibits	disease	0.50

Incoming (7)

Source	Relation	Type	Str
NAD	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
NEURON	inhibits	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
AND	inhibits	gene	0.60
AXON	inhibits	gene	0.60
SARM1	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NMNAT1 in their description or question text

No additional research found