gene

NDUFS8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NDUFS8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

41Connections

0Hypotheses

0Analyses

23Outgoing

18Incoming

0Experiments

0Debates

Summary

Comprehensive gene page for NDUFS8, encoding a critical iron-sulfur subunit of mitochondrial Complex I, implicated in Parkinson's disease, Leigh syndrome, and other neurodegenerative disorders

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🧬 Gene Info

Gene Symbol	NDUFS8
Full Name	NADH:Ubiquinone Oxidoreductase Core Subunit S8
Chromosome	19q13.42
Function	encodes a critical iron-sulfur protein subunit of mitochondrial Complex I (NADH:ubiquinone oxidoreductase), the largest and most complex enzyme of the mitochondrial electron transport chain.
Primary Expression	Brain, Heart, Skeletal Muscle, Liver, Kidney
Molecular Weight	23 kDa
Amino Acids	210 aa
Exons	5
UniProt ID	P51970
NCBI Gene ID	4728
Ensembl ID	ENSG00000110717
OMIM	602140
GeneCards	NDUFS8
Human Protein Atlas	NDUFS8
Associated Diseases	Parkinson's Disease, Leigh Syndrome, Mitochondrial Complex I Deficiency
KG Connections	41 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NDUFS8 — AlphaFold P51970 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NDUFS8 — NADH:Ubiquinone Oxidoreductase Core Subunit S8

gene · 2606 words

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Pathway Diagram

graph TD
    NDUFS8["NDUFS8"]
    Alzheimer{"Alzheimer"}
    NDUFS8 -->|"expressed in"| Alzheimer
    Cancer{"Cancer"}
    NDUFS8 -->|"expressed in"| Cancer
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    NDUFS8 -->|"expressed in"| ALZHEIMER_S_DISEASE
    CYTOKINES["CYTOKINES"]
    NDUFS8 -->|"expressed in"| CYTOKINES
    LDLR["LDLR"]
    NDUFS8 -->|"expressed in"| LDLR
    ALZHEIMER_DISEASE["ALZHEIMER DISEASE"]
    NDUFS8 -->|"expressed in"| ALZHEIMER_DISEASE
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    NDUFS8 -->|"expressed in"| MITOCHONDRIAL_DYSFUNCTION
    CLU["CLU"]
    NDUFS8 -->|"regulates"| CLU
    SPG7["SPG7"]
    NDUFS8 -->|"regulates"| SPG7
    MAPT["MAPT"]
    NDUFS8 -->|"regulates"| MAPT
    Epigenetic(["Epigenetic"])
    NDUFS8 -->|"expressed in"| Epigenetic
    Dna_Methylation(["Dna Methylation"])
    NDUFS8 -->|"expressed in"| Dna_Methylation
    ACE["ACE"]
    ACE -->|"expressed in"| NDUFS8
    PHGDH["PHGDH"]
    PHGDH -->|"biomarker for"| NDUFS8
    HK2["HK2"]
    HK2 -->|"biomarker for"| NDUFS8
    CANCER["CANCER"]
    CANCER -->|"expressed in"| NDUFS8
    SMAD3["SMAD3"]
    SMAD3 -->|"biomarker for"| NDUFS8
    style NDUFS8 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (23)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:NDUFS8	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Alzheimer Disease	risk_factor_for	disease	0.85
Alzheimer	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Interleukin	expressed_in	protein	0.60
Cytokine	expressed_in	protein	0.60
Hepatocyte	expressed_in	cell_type	0.60
DNA	expressed_in	gene	0.60
GENES	regulates	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
AND	regulates	gene	0.60
LDLR	expressed_in	gene	0.60
CLU	regulates	gene	0.60
SPG7	regulates	gene	0.60
MAPT	regulates	gene	0.60
CYTOKINES	expressed_in	gene	0.60
ALZHEIMER DISEASE	expressed_in	gene	0.60
MITOCHONDRIAL DYSFUNCTION	expressed_in	gene	0.60
Epigenetic	expressed_in	pathway	0.60
Dna Methylation	expressed_in	pathway	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
ACE	expressed_in	gene	0.60

Incoming (18)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:NDUFS8	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
GENES	regulates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	expressed_in	gene	0.60
ALZHEIMER DISEASE	expressed_in	gene	0.60
CYTOKINES	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
PHGDH	biomarker_for	gene	0.60
CANCER	expressed_in	gene	0.60
DNA	expressed_in	gene	0.60
ACE	expressed_in	gene	0.60
HK2	biomarker_for	gene	0.60
SMAD3	biomarker_for	gene	0.60
CLU	regulates	gene	0.60
SPG7	regulates	gene	0.60
MAPT	regulates	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
LDLR	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NDUFS8 in their description or question text

No additional research found