gene

DOCK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DOCK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12Connections

0Hypotheses

0Analyses

5Outgoing

7Incoming

0Experiments

0Debates

Summary

Comprehensive coverage of DOCK1 (Dedicator of Cytokinesis 1), a Rac-specific guanine nucleotide exchange factor implicated in neuronal development, synaptic plasticity, and neurodegenerative diseases including AD/PD.

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🧬 Gene Info

Gene Symbol	DOCK1
Full Name	Dedicator of Cytokinesis 1
Chromosome	10q26.3
Function	is a member of the DOCK family of guanine nucleotide exchange factors (GEFs) that specifically activate Rho GTPases, particularly Rac1.
Primary Expression	Brain, Heart, Liver, Lung, Kidney
Molecular Weight	210 kDa
Amino Acids	1864 aa
Exons	35
UniProt ID	Q8IU85
NCBI Gene ID	1791
Ensembl ID	ENSG00000123146
OMIM	606003
GeneCards	DOCK1
Human Protein Atlas	DOCK1
Associated Diseases	Alzheimer's disease, Parkinson's disease
KG Connections	12 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DOCK1 — AlphaFold Q8IU85 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DOCK1 Gene

gene · 2503 words

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Pathway Diagram

graph TD
    DOCK1["DOCK1"]
    Als{"Als"}
    DOCK1 -->|"regulates"| Als
    Ms{"Ms"}
    DOCK1 -->|"regulates"| Ms
    NDUFA12["NDUFA12"]
    DOCK1 -->|"associated with"| NDUFA12
    YWHAH["YWHAH"]
    DOCK1 -->|"associated with"| YWHAH
    NDUFS5["NDUFS5"]
    DOCK1 -->|"associated with"| NDUFS5
    neurodegeneration["neurodegeneration"]
    DOCK1 -->|"implicated in"| neurodegeneration
    NDUFA2["NDUFA2"]
    NDUFA2 -->|"associated with"| DOCK1
    NDUFS6["NDUFS6"]
    NDUFS6 -->|"associated with"| DOCK1
    NDUFA1["NDUFA1"]
    NDUFA1 -->|"associated with"| DOCK1
    CBL["CBL"]
    CBL -->|"associated with"| DOCK1
    PDGFRB["PDGFRB"]
    PDGFRB -->|"associated with"| DOCK1
    HSP90AB1["HSP90AB1"]
    HSP90AB1 -->|"associated with"| DOCK1
    CRKL["CRKL"]
    CRKL -->|"associated with"| DOCK1
    style DOCK1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (5)

Target	Relation	Type	Str
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
NDUFA12	associated_with	gene	0.60
YWHAH	associated_with	gene	0.60
NDUFS5	associated_with	gene	0.60

Incoming (7)

Source	Relation	Type	Str
NDUFA2	associated_with	gene	0.60
NDUFS6	associated_with	gene	0.60
NDUFA1	associated_with	gene	0.60
CBL	associated_with	gene	0.60
PDGFRB	associated_with	gene	0.60
HSP90AB1	associated_with	gene	0.60
CRKL	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DOCK1 in their description or question text

No additional research found